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. 1990 Apr;10(4):1773–1778. doi: 10.1128/mcb.10.4.1773

Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma.

A de Bustros 1, R Y Lee 1, D Compton 1, T Y Tsong 1, S B Baylin 1, B D Nelkin 1
PMCID: PMC362284  PMID: 2157143

Abstract

Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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