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. 1989 Jul;9(7):3122–3126. doi: 10.1128/mcb.9.7.3122

Tissue-specific in vitro transcription from the mouse myelin basic protein promoter.

T Tamura 1, A Aoyama 1, T Inoue 1, M Miura 1, H Okano 1, K Mikoshiba 1
PMCID: PMC362786  PMID: 2476662

Abstract

The mouse myelin basic protein promoter was transcribed in brain nuclear extracts. The distal promoter region from -253 to -54 directed preferential transcription in brain extracts, whereas the same region repressed transcription activity in liver extracts. Stimulation of transcription was observed when the distal region was located only in a native orientation. The proximal region downstream from -53 alone still directed preferential transcription. It is suggested that cooperative function by the two promoter regions may be required for higher specificity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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