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. 1990 Oct;1(11):853–861. doi: 10.1091/mbc.1.11.853

Latency correlates with period in a model for signal-induced Ca2+ oscillations based on Ca2(+)-induced Ca2+ release.

G Dupont 1, M J Berridge 1, A Goldbeter 1
PMCID: PMC362852  PMID: 2088529

Abstract

Oscillations in cytosolic Ca2+ develop in a variety of cells after an induction phase, called latency, the duration of which depends on the magnitude of external stimulation. Experiments in hepatocytes indicate that the period and latency of Ca2+ oscillations both decrease as the level of the stimulus increases. We analyze the correlation between period and latency in a model recently proposed for signal-induced Ca2+ oscillations. We show that the linear relationship between period and latency observed in the experiments arises naturally in this model as a result of the mechanism of Ca2(+)-induced Ca2+ release on which it is based.

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Selected References

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  1. Backx P. H., de Tombe P. P., Van Deen J. H., Mulder B. J., ter Keurs H. E. A model of propagating calcium-induced calcium release mediated by calcium diffusion. J Gen Physiol. 1989 May;93(5):963–977. doi: 10.1085/jgp.93.5.963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berridge M. J. Calcium oscillations. J Biol Chem. 1990 Jun 15;265(17):9583–9586. [PubMed] [Google Scholar]
  3. Berridge M. J., Cobbold P. H., Cuthbertson K. S. Spatial and temporal aspects of cell signalling. Philos Trans R Soc Lond B Biol Sci. 1988 Jul 26;320(1199):325–343. doi: 10.1098/rstb.1988.0080. [DOI] [PubMed] [Google Scholar]
  4. Berridge M. J., Galione A. Cytosolic calcium oscillators. FASEB J. 1988 Dec;2(15):3074–3082. doi: 10.1096/fasebj.2.15.2847949. [DOI] [PubMed] [Google Scholar]
  5. Berridge M. J., Irvine R. F. Inositol phosphates and cell signalling. Nature. 1989 Sep 21;341(6239):197–205. doi: 10.1038/341197a0. [DOI] [PubMed] [Google Scholar]
  6. Berridge M. J. The Croonian lecture, 1988. Inositol lipids and calcium signalling. Proc R Soc Lond B Biol Sci. 1988 Sep 22;234(1277):359–378. doi: 10.1098/rspb.1988.0054. [DOI] [PubMed] [Google Scholar]
  7. Busa W. B., Ferguson J. E., Joseph S. K., Williamson J. R., Nuccitelli R. Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores. J Cell Biol. 1985 Aug;101(2):677–682. doi: 10.1083/jcb.101.2.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Busa W. B., Nuccitelli R. An elevated free cytosolic Ca2+ wave follows fertilization in eggs of the frog, Xenopus laevis. J Cell Biol. 1985 Apr;100(4):1325–1329. doi: 10.1083/jcb.100.4.1325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Capiod T., Field A. C., Ogden D. C., Sandford C. A. Internal perfusion of guinea-pig hepatocytes with buffered Ca2+ or inositol 1,4,5-trisphosphate mimics noradrenaline activation of K+ and Cl- conductances. FEBS Lett. 1987 Jun 15;217(2):247–252. doi: 10.1016/0014-5793(87)80672-5. [DOI] [PubMed] [Google Scholar]
  10. Cheer A., Vincent J. P., Nuccitelli R., Oster G. Cortical activity in vertebrate eggs. I: The activation waves. J Theor Biol. 1987 Feb 21;124(4):377–404. doi: 10.1016/s0022-5193(87)80217-5. [DOI] [PubMed] [Google Scholar]
  11. Cornell-Bell A. H., Finkbeiner S. M., Cooper M. S., Smith S. J. Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science. 1990 Jan 26;247(4941):470–473. doi: 10.1126/science.1967852. [DOI] [PubMed] [Google Scholar]
  12. Endo M., Tanaka M., Ogawa Y. Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature. 1970 Oct 3;228(5266):34–36. doi: 10.1038/228034a0. [DOI] [PubMed] [Google Scholar]
  13. Fabiato A., Fabiato F. Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells. J Physiol. 1975 Aug;249(3):469–495. doi: 10.1113/jphysiol.1975.sp011026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Gilkey J. C., Jaffe L. F., Ridgway E. B., Reynolds G. T. A free calcium wave traverses the activating egg of the medaka, Oryzias latipes. J Cell Biol. 1978 Feb;76(2):448–466. doi: 10.1083/jcb.76.2.448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Goldbeter A., Dupont G. Allosteric regulation, cooperativity, and biochemical oscillations. Biophys Chem. 1990 Aug 31;37(1-3):341–353. doi: 10.1016/0301-4622(90)88033-o. [DOI] [PubMed] [Google Scholar]
  16. Goldbeter A., Dupont G., Berridge M. J. Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1461–1465. doi: 10.1073/pnas.87.4.1461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Harootunian A. T., Kao J. P., Tsien R. Y. Agonist-induced calcium oscillations in depolarized fibroblasts and their manipulation by photoreleased Ins(1,4,5)P3, Ca++, and Ca++ buffer. Cold Spring Harb Symp Quant Biol. 1988;53(Pt 2):935–943. doi: 10.1101/sqb.1988.053.01.108. [DOI] [PubMed] [Google Scholar]
  18. Jacob R., Merritt J. E., Hallam T. J., Rink T. J. Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells. Nature. 1988 Sep 1;335(6185):40–45. doi: 10.1038/335040a0. [DOI] [PubMed] [Google Scholar]
  19. Jaffe L. F. Sources of calcium in egg activation: a review and hypothesis. Dev Biol. 1983 Oct;99(2):265–276. doi: 10.1016/0012-1606(83)90276-2. [DOI] [PubMed] [Google Scholar]
  20. Kuba K., Takeshita S. Simulation of intracellular Ca2+ oscillation in a sympathetic neurone. J Theor Biol. 1981 Dec 21;93(4):1009–1031. doi: 10.1016/0022-5193(81)90352-0. [DOI] [PubMed] [Google Scholar]
  21. Marty A., Tan Y. P. The initiation of calcium release following muscarinic stimulation in rat lacrimal glands. J Physiol. 1989 Dec;419:665–687. doi: 10.1113/jphysiol.1989.sp017892. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Meyer T., Stryer L. Molecular model for receptor-stimulated calcium spiking. Proc Natl Acad Sci U S A. 1988 Jul;85(14):5051–5055. doi: 10.1073/pnas.85.14.5051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Miledi R., Parker I. Latencies of membrane currents evoked in Xenopus oocytes by receptor activation, inositol trisphosphate and calcium. J Physiol. 1989 Aug;415:189–210. doi: 10.1113/jphysiol.1989.sp017718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Neher E., Marty A., Fukuda K., Kubo T., Numa S. Intracellular calcium release mediated by two muscarinic receptor subtypes. FEBS Lett. 1988 Nov 21;240(1-2):88–94. doi: 10.1016/0014-5793(88)80345-4. [DOI] [PubMed] [Google Scholar]
  25. Osipchuk Y. V., Wakui M., Yule D. I., Gallacher D. V., Petersen O. H. Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells. EMBO J. 1990 Mar;9(3):697–704. doi: 10.1002/j.1460-2075.1990.tb08162.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Parker I., Sumikawa K., Miledi R. Activation of a common effector system by different brain neurotransmitter receptors in Xenopus oocytes. Proc R Soc Lond B Biol Sci. 1987 Jun 22;231(1262):37–45. doi: 10.1098/rspb.1987.0034. [DOI] [PubMed] [Google Scholar]
  27. Putney J. W., Jr A model for receptor-regulated calcium entry. Cell Calcium. 1986 Feb;7(1):1–12. doi: 10.1016/0143-4160(86)90026-6. [DOI] [PubMed] [Google Scholar]
  28. Quinn S. J., Williams G. H., Tillotson D. L. Calcium oscillations in single adrenal glomerulosa cells stimulated by angiotensin II. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5754–5758. doi: 10.1073/pnas.85.15.5754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Rink T. J., Jacob R. Calcium oscillations in non-excitable cells. Trends Neurosci. 1989 Feb;12(2):43–46. doi: 10.1016/0166-2236(89)90133-1. [DOI] [PubMed] [Google Scholar]
  30. Rooney T. A., Sass E. J., Thomas A. P. Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes. J Biol Chem. 1990 Jun 25;265(18):10792–10796. [PubMed] [Google Scholar]
  31. Rooney T. A., Sass E. J., Thomas A. P. Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes. J Biol Chem. 1989 Oct 15;264(29):17131–17141. [PubMed] [Google Scholar]
  32. Sage S. O., Rink T. J. The kinetics of changes in intracellular calcium concentration in fura-2-loaded human platelets. J Biol Chem. 1987 Dec 5;262(34):16364–16369. [PubMed] [Google Scholar]
  33. Takamatsu T., Wier W. G. Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity. FASEB J. 1990 Mar;4(5):1519–1525. doi: 10.1096/fasebj.4.5.2307330. [DOI] [PubMed] [Google Scholar]
  34. Wakui M., Potter B. V., Petersen O. H. Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration. Nature. 1989 May 25;339(6222):317–320. doi: 10.1038/339317a0. [DOI] [PubMed] [Google Scholar]
  35. Woods N. M., Cuthbertson K. S., Cobbold P. H. Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes. Cell Calcium. 1987 Feb;8(1):79–100. doi: 10.1016/0143-4160(87)90038-8. [DOI] [PubMed] [Google Scholar]

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