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. 1987 Jan;7(1):535–540. doi: 10.1128/mcb.7.1.535

The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

W Chang, C Upton, S L Hu, A F Purchio, G McFadden
PMCID: PMC365099  PMID: 3031480

Abstract

Degenerate oligonucleotide probes corresponding to a highly conserved region common to epidermal growth factor, transforming growth factor alpha, and vaccinia growth factor were used to identify a novel growth factor gene in the Shope fibroma virus genome. Sequence analysis indicates that the Shope fibroma growth factor is a distinct new member of this family of growth factors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEARCROFT W. G., JAMIESON M. F. An outbreak of subcutaneous tumours in rhesus monkeys. Nature. 1958 Jul 19;182(4629):195–196. doi: 10.1038/182195a0. [DOI] [PubMed] [Google Scholar]
  2. Block W., Upton C., McFadden G. Tumorigenic poxviruses: genomic organization of malignant rabbit virus, a recombinant between Shope fibroma virus and myxoma virus. Virology. 1985 Jan 15;140(1):113–124. doi: 10.1016/0042-6822(85)90450-7. [DOI] [PubMed] [Google Scholar]
  3. Blomquist M. C., Hunt L. T., Barker W. C. Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7363–7367. doi: 10.1073/pnas.81.23.7363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown J. P., Twardzik D. R., Marquardt H., Todaro G. J. Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor. Nature. 1985 Feb 7;313(6002):491–492. doi: 10.1038/313491a0. [DOI] [PubMed] [Google Scholar]
  5. Brown S. T., Nalley J. F., Kraus S. J. Molluscum contagiosum. Sex Transm Dis. 1981 Jul-Sep;8(3):227–234. doi: 10.1097/00007435-198107000-00012. [DOI] [PubMed] [Google Scholar]
  6. Delange A. M., Macaulay C., Block W., Mueller T., McFadden G. Tumorigenic poxviruses: construction of the composite physical map of the Shope fibroma virus genome. J Virol. 1984 May;50(2):408–416. doi: 10.1128/jvi.50.2.408-416.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goustin A. S., Leof E. B., Shipley G. D., Moses H. L. Growth factors and cancer. Cancer Res. 1986 Mar;46(3):1015–1029. [PubMed] [Google Scholar]
  8. Heldin C. H., Westermark B. Growth factors: mechanism of action and relation to oncogenes. Cell. 1984 May;37(1):9–20. doi: 10.1016/0092-8674(84)90296-4. [DOI] [PubMed] [Google Scholar]
  9. James R., Bradshaw R. A. Polypeptide growth factors. Annu Rev Biochem. 1984;53:259–292. doi: 10.1146/annurev.bi.53.070184.001355. [DOI] [PubMed] [Google Scholar]
  10. King C. S., Cooper J. A., Moss B., Twardzik D. R. Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors. Mol Cell Biol. 1986 Jan;6(1):332–336. doi: 10.1128/mcb.6.1.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Reisner A. H. Similarity between the vaccinia virus 19K early protein and epidermal growth factor. 1985 Feb 28-Mar 6Nature. 313(6005):801–803. doi: 10.1038/313801a0. [DOI] [PubMed] [Google Scholar]
  12. Roberts A. B., Sporn M. B. Transforming growth factors. Cancer Surv. 1985;4(4):683–705. [PubMed] [Google Scholar]
  13. Sell S., Scott C. B. An immunohistologic study of Shope fibroma virus in rabbits: tumor rejection by cellular reaction in adults and progressive systemic reticuloendothelial infection in neonates. J Natl Cancer Inst. 1981 Feb;66(2):363–373. [PubMed] [Google Scholar]
  14. Spriggs D. R. Vaccinia virus growth factor: a surprising catch. J Infect Dis. 1986 Feb;153(2):382–383. doi: 10.1093/infdis/153.2.382. [DOI] [PubMed] [Google Scholar]
  15. Stroobant P., Rice A. P., Gullick W. J., Cheng D. J., Kerr I. M., Waterfield M. D. Purification and characterization of vaccinia virus growth factor. Cell. 1985 Aug;42(1):383–393. doi: 10.1016/s0092-8674(85)80133-1. [DOI] [PubMed] [Google Scholar]
  16. Tompkins W. A., Schultz R. M., Rao G. V. Depressed cell-mediated immunity in newborn rabbits bearing fibroma virus-induced tumors. Infect Immun. 1973 Apr;7(4):613–619. doi: 10.1128/iai.7.4.613-619.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Twardzik D. R., Brown J. P., Ranchalis J. E., Todaro G. J., Moss B. Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5300–5304. doi: 10.1073/pnas.82.16.5300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Upton C., McFadden G. DNA sequence homology between the terminal inverted repeats of Shope fibroma virus and an endogenous cellular plasmid species. Mol Cell Biol. 1986 Jan;6(1):265–276. doi: 10.1128/mcb.6.1.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Upton C., McFadden G. Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus. Virology. 1986 Jul 30;152(2):308–321. doi: 10.1016/0042-6822(86)90134-0. [DOI] [PubMed] [Google Scholar]
  20. Wills A., Delange A. M., Gregson C., Macaulay C., McFadden G. Physical characterization and molecular cloning of the Shope fibroma virus DNA genome. Virology. 1983 Oct 30;130(2):403–414. doi: 10.1016/0042-6822(83)90095-8. [DOI] [PubMed] [Google Scholar]

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