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. 1987 Feb;7(2):936–939. doi: 10.1128/mcb.7.2.936

Extinction of expression of immunoglobulin genes in myeloma X fibroblast somatic cell hybrids.

A Greenberg, R Ber, Z Kra-Oz, R Laskov
PMCID: PMC365154  PMID: 3102948

Abstract

Adherent hybrids between immunoglobulin-producing mouse myeloma cells and fibroblasts do not produce immunoglobulin polypeptide chains. These hybrids retained the actively rearranged immunoglobulin genes of the myeloma parental cells but lacked immunoglobulin heavy- and light-chain RNA transcripts. We conclude that the shutoff of immunoglobulin production in these hybrids occurs at the transcription or early processing level.

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