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. 1987 Apr;7(4):1320–1325. doi: 10.1128/mcb.7.4.1320

Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes.

M A Labow, L H Graf Jr, K I Berns
PMCID: PMC365216  PMID: 3037312

Abstract

In this paper we report that adeno-associated virus (AAV) genomes inhibit stable transformation by several dominant selectable marker genes upon cotransfection into mouse tissue culture cells. Cotransfection of AAV genomes also inhibited the expression of pSV2cat in transient assays. In both cases, the inhibitory effect was independent of AAV DNA replication but required the AAV p5 and p19 genes, which encode proteins required for AAV DNA replication and regulation of AAV gene expression. Finally, addition of a cloned E4 gene in the transfection experiments partially blocked the AAV-mediated inhibitory activities.

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Selected References

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