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. 1987 Jul;7(7):2644–2648. doi: 10.1128/mcb.7.7.2644

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.

J B Trepel, O R Colamonici, K Kelly, G Schwab, R A Watt, E A Sausville, E S Jaffe, L M Neckers
PMCID: PMC365406  PMID: 3039354

Abstract

Treatment of HL-60 cells with dibutyryl cyclic AMP induced rapid transcriptional inactivation of c-myc and the transferrin receptor. Transcriptional inactivation was followed by loss of c-myc and transferrin receptor mRNA and protein. Treated cells completed one round of proliferation, followed by growth arrest, G1 synchronization, and monocytic differentiation. These data suggest that cyclic AMP-mediated control of growth and differentiation may be achieved, at least in part, by transcriptional regulation of certain growth-associated proto-oncogenes and growth factor receptor genes.

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