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. 1988 Sep;8(9):3847–3856. doi: 10.1128/mcb.8.9.3847

Transcriptional unit of the murine Thy-1 gene: different distribution of transcription initiation sites in brain.

E Spanopoulou 1, V Giguere 1, F Grosveld 1
PMCID: PMC365443  PMID: 2906111

Abstract

Structural analysis of the mouse Thy-1.2 gene has shown that the major promoter of the gene is characterized by a tissue-specific DNase I-hypersensitive site and is located within a methylation-free island. The gene is regulated at the transcriptional level, and steady-state mRNA analysis reveals that the previously reported exon Ib contributes at most 5% of the total mRNA. The major promoter uses several transcription initiation sites within a region of 100 base pairs. The frequency of usage of these sites in brain is markedly different from that in other tissues.

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