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. 1988 Sep;8(9):3934–3937. doi: 10.1128/mcb.8.9.3934

Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells.

K Takenaga 1, Y Nakamura 1, S Sakiyama 1
PMCID: PMC365453  PMID: 3221870

Abstract

Two-dimensional electrophoretograms of newly synthesized polypeptides from low-metastatic (P29) and high-metastatic (D6) Lewis lung carcinoma cells were compared. The results showed that the synthesis of tropomyosin 2 (TM2) was significantly less in D6 cells than in P29 cells. Furthermore, suppression of TM2 synthesis was induced in P29 cells during incubation in medium containing dimethyl sulfoxide or butyric acid, which induced the metastatic phenotype of P29 cells. These results suggest that the suppression of TM2 synthesis is linked to the metastatic potential of Lewis lung carcinoma cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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