Abstract
The influence of naturally occurring phenolic acids on phosphate uptake by barley (Hordeum vulgare L. cv. Karlsberg) roots was examined using 32P-labeled phosphate. Without exception, all compounds tested, namely, benzoic, 2-hydroxybenzoic, 4-hydroxybenzoic, 3,4-dihydroxybenzoic, 3,4,5-trihydroxybenzoic, 4-hydroxy-3-methoxybenzoic, 4-hydroxy-3,5-dimethoxybenzoic, cinnamic, 2-hydroxycinnamic, 4-hydroxycinnamic, 3,4-dihydroxycinnamic, 4-hydroxy-3-methoxycinnamic, and 4-hydroxy-3,5-dimethoxycinnamic acids, inhibited uptake.
The degree of inhibition correlated well with the lipid solubility of these phenolic compounds. This as well as kinetic data support the hypothesis of inhibition through altered membrane properties.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALVARADO F., CRANE R. K. STUDIES ON THE MECHANISM OF INTESTINAL ABSORPTION OF SUGARS. VII. PHENYLGLYCOSIDE TRANSPORT AND ITS POSSIBLE RELATIONSHIP TO PHLORIZIN INHIBITION OF THE ACTIVE TRANSPORT OF SUGARS BY THE SMALL INTESTINE. Biochim Biophys Acta. 1964 Oct 9;93:116–135. doi: 10.1016/0304-4165(64)90266-1. [DOI] [PubMed] [Google Scholar]
- Epstein E., Hagen C. E. A KINETIC STUDY OF THE ABSORPTION OF ALKALI CATIONS BY BARLEY ROOTS. Plant Physiol. 1952 Jul;27(3):457–474. doi: 10.1104/pp.27.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gaur B. K., Beevers H. Respiratory and Associated Responses of Carrot Disc to Substituted Phenols. Plant Physiol. 1959 Jul;34(4):427–432. doi: 10.1104/pp.34.4.427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARBORNE J. B., CORNER J. J. Plant polyphenols. 4. Hydroxycinnamic acid-sugar derivatives. Biochem J. 1961 Nov;81:242–250. doi: 10.1042/bj0810242. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOGBEN C. A. The alimentary tract. Annu Rev Physiol. 1960;22:381–406. doi: 10.1146/annurev.ph.22.030160.002121. [DOI] [PubMed] [Google Scholar]
- Levitan H., Barker J. L. Salicylate: a structure-activity study of its effects on membrane permeability. Science. 1972 Jun 30;176(4042):1423–1425. doi: 10.1126/science.176.4042.1423. [DOI] [PubMed] [Google Scholar]
- MITCHELL P. Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature. 1961 Jul 8;191:144–148. doi: 10.1038/191144a0. [DOI] [PubMed] [Google Scholar]
- WHITEHEAD D. C. IDENTIFICATION OF P-HYDROXYBENZOIC, VANILLIC, P-COUMARIC AND FERULIC ACIDS IN SOILS. Nature. 1964 Apr 25;202:417–418. doi: 10.1038/202417a0. [DOI] [PubMed] [Google Scholar]
- Whittaker R. H., Feeny P. P. Allelochemics: chemical interactions between species. Science. 1971 Feb 26;171(3973):757–770. doi: 10.1126/science.171.3973.757. [DOI] [PubMed] [Google Scholar]