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. 1985 Feb;5(2):414–418. doi: 10.1128/mcb.5.2.414

Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells.

M Shibuya, J Yokota, Y Ueyama
PMCID: PMC366726  PMID: 2579323

Abstract

Three of 16 human gastric adenocarcinoma samples, maintained as solid tumors in nude mice, were found to carry amplified c-myc genes. In two samples with a high degree of c-myc DNA amplification (15- to 30-fold), double minute chromosomes were observed in karyotype analysis. The level of c-myc RNA was markedly elevated in a rapidly growing and poorly differentiated tumor, whereas it was only slightly elevated in a slowly growing and more differentiated tumor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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