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. 1986 Oct;6(10):3531–3536. doi: 10.1128/mcb.6.10.3531

Overproduction of protein p53 contributes to simian virus 40-mediated transformation.

D Michalovitz, D Eliyahu, M Oren
PMCID: PMC367102  PMID: 3025598

Abstract

The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.

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Selected References

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