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. 1986 Nov;6(11):4140–4143. doi: 10.1128/mcb.6.11.4140

Dissociated expression of c-myc and a fos-related competence gene during cardiac myogenesis.

M D Schneider, P A Payne, H Ueno, M B Perryman, R Roberts
PMCID: PMC367187  PMID: 3796601

Abstract

Cardiac myocytes irreversibly lose their proliferative capacity soon after birth, and cardiac DNA synthesis becomes uncoupled from mitotic division. Therefore, we examined cardiac muscle for developmental down regulation of inducible proto-oncogenes associated with cell proliferation. c-myc mRNA decreased continuously from day 13 of embryonic development and was dissociated from expression of the fos-related gene r-fos, which decreased precipitously between days 3 and 7 after birth.

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Selected References

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