Abstract
Rabbits have a minimum of two polymeric immunoglobulin receptor primary translation products. A cDNA clone of the smaller product lacked two of the five receptor domains. These two domains were on a single exon. As there was one receptor gene, we suggest that this exon can be spliced in or out.
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- Early P., Rogers J., Davis M., Calame K., Bond M., Wall R., Hood L. Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell. 1980 Jun;20(2):313–319. doi: 10.1016/0092-8674(80)90617-0. [DOI] [PubMed] [Google Scholar]
- Eiffert H., Quentin E., Decker J., Hillemeir S., Hufschmidt M., Klingmüller D., Weber M. H., Hilschmann N. Die Primärstruktur der menschlichen freien Sekretkomponente und die Anordnung der Disulfidbrücken. Hoppe Seylers Z Physiol Chem. 1984 Dec;365(12):1489–1495. [PubMed] [Google Scholar]
- King C. R., Piatigorsky J. Alternative splicing of alpha A-crystallin RNA. Structural and quantitative analyses of the mRNAs for the alpha A2- and alpha Ains-crystallin polypeptides. J Biol Chem. 1984 Feb 10;259(3):1822–1826. [PubMed] [Google Scholar]
- Knight K. L., Burnett R. C., McNicholas J. M. Organization and polymorphism of rabbit immunoglobulin heavy chain genes. J Immunol. 1985 Feb;134(2):1245–1250. [PubMed] [Google Scholar]
- Knight K. L., Rosenzweig M., Lichter E. A., Hanly W. C. Rabbit secretory IgA: identification and genetic control of two allotypes of secretory component. J Immunol. 1974 Mar;112(3):877–882. [PubMed] [Google Scholar]
- Kühn L. C., Kocher H. P., Hanly W. C., Cook L., Jaton J. C., Kraehenbuhl J. P. Structural and genetic heterogeneity of the receptor mediating translocation of immunoglobulin A dimer antibodies across epithelia in the rabbit. J Biol Chem. 1983 May 25;258(10):6653–6659. [PubMed] [Google Scholar]
- Kühn L. C., Kraehenbuhl J. P. Interaction of rabbit secretory component with rabbit IgA dimer. J Biol Chem. 1979 Nov 10;254(21):11066–11071. [PubMed] [Google Scholar]
- Mostov K. E., Blobel G. A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins. J Biol Chem. 1982 Oct 10;257(19):11816–11821. [PubMed] [Google Scholar]
- Mostov K. E., Friedlander M., Blobel G. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature. 1984 Mar 1;308(5954):37–43. doi: 10.1038/308037a0. [DOI] [PubMed] [Google Scholar]
- Mostov K. E., Kraehenbuhl J. P., Blobel G. Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7257–7261. doi: 10.1073/pnas.77.12.7257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mount S. M. A catalogue of splice junction sequences. Nucleic Acids Res. 1982 Jan 22;10(2):459–472. doi: 10.1093/nar/10.2.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sullivan D. A., Wira C. R. Variations in free secretory component levels in mucosal secretions of the rat. J Immunol. 1983 Mar;130(3):1330–1335. [PubMed] [Google Scholar]
- Takahashi N., Roach A., Teplow D. B., Prusiner S. B., Hood L. Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell. 1985 Aug;42(1):139–148. doi: 10.1016/s0092-8674(85)80109-4. [DOI] [PubMed] [Google Scholar]