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. 1982 Jul;2(7):829–836. doi: 10.1128/mcb.2.7.829

Immunoglobulin gene rearrangements in normal mouse B cells.

P Early, C Nottenburg, I Weissman, L Hood
PMCID: PMC369865  PMID: 6821506

Abstract

We have analyzed the structure of rearranged mu heavy-chain genes obtained from the genomic DNA of normal BALB/c mouse spleen cells expressing surface immunoglobulin M. Examples were found of two types of nonproductive rearrangements, which may be responsible for allelic exclusion in normal B cells. In one of these rearrangements, a germ line D gene segment has joined to the JH4 gene segment but no V/D joining has occurred. We present evidence that D gene segments lie as a cluster between V and J gene segments in the germ line. A comparison of conserved sequences in V and D gene segments suggests that the D gene segments, which are found only in the heavy-chain gene family, may have evolved from V gene segments similar to the Vk family.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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