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. 1982 Oct;2(10):1295–1298. doi: 10.1128/mcb.2.10.1295

Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.

B F Cheetham, D C Shaw, A J Bellett
PMCID: PMC369929  PMID: 7177112

Abstract

Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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