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. 1981 Mar;67(3):878–884. doi: 10.1172/JCI110105

Heterogeneity of DNA deletion in gamma delta beta-thalassemia.

S H Orkin, S C Goff, D G Nathan
PMCID: PMC370639  PMID: 6162860

Abstract

By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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