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. 1979 Nov;64(5):1530–1534. doi: 10.1172/JCI109612

Cross-idiotypic antigens among monoclonal immunoglobulin M from patients with Waldenström's macroglobulinemia and polyneuropathy.

K Dellagi, J C Brouet, F Danon
PMCID: PMC371303  PMID: 91626

Abstract

The monoclonal immunoglobulin (Ig)M from 5 to 16 patients with Waldenström's macroglobulinemia and a polyneuropathy shared cross-idiotypic antigenic determinants as demonstrated by hemagglutination and hemagglutination inhibition experiments as well as by precipitin reactions. This reactivity was located to the Fab (and not Fc) fragment of the protein. The IgM from 73 patients with macroglobulinemia but without neuropathy all gave negative reactions. In contrast, the monoclonal IgG from a patient with polyneuropathy also possessed similar idiotypic determinants. Since cross-idiotypic determinants are usually related to the combining site of a monoclonal Ig, this finding suggests that the monoclonal Ig of these patients may mediate the nerve injury via their antibody activity, which could be directed either to a nerve antigen or to some component involved in the pathogenesis of the neuropathy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarli J. A., Aparicio S. R., Lumsden C. E., Tönder O. Binding of normal human IgG to myelin sheaths, glia and neurons. Immunology. 1975 Jan;28(1):171–185. [PMC free article] [PubMed] [Google Scholar]
  2. Björnsson O. G., Arnason A., Gudmunosson S., Jensson O., Olafsson S., Valimarsson H. Macroglobulinaemia in an Icelandic family. Acta Med Scand. 1978;203(4):283–288. doi: 10.1111/j.0954-6820.1978.tb14874.x. [DOI] [PubMed] [Google Scholar]
  3. Capra J. D., Klapper D. G. Complete amino acid sequence of the variable domains of two human IgM anti-gamma globulins (Lay/Pom) with shared idiotypic specificities. Scand J Immunol. 1976;5(6-7):677–684. doi: 10.1111/j.1365-3083.1976.tb03017.x. [DOI] [PubMed] [Google Scholar]
  4. Chazot G., Berger G., Bady B., Dumas R., Creysel R., Tommasi M., Schott B., Girard P. Neuropathie périphérique au cours des dysglobulinémies malignes. Aspects immunopathologiques. Nouv Presse Med. 1974 May 25;3(21):1355–1358. [PubMed] [Google Scholar]
  5. Ebers G. C., Zabriskie J. B., Kunkel H. G. Oligoclonal immunoglobulins in subacute sclerosing panencephalitis and multiple sclerosis: a study of idiotypic determinants. Clin Exp Immunol. 1979 Jan;35(1):67–75. [PMC free article] [PubMed] [Google Scholar]
  6. Feizi T., Kunkel H. G., Roelcke D. Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens. Clin Exp Immunol. 1974 Oct;18(2):283–293. [PMC free article] [PubMed] [Google Scholar]
  7. Forssman O., Björkman G., Hollender A., Englund N. E. IgM-producing lymphocytes in peripheral nerve in a patient with benign monoclonal gammopathy. Scand J Haematol. 1973;11(4):332–335. doi: 10.1111/j.1600-0609.1973.tb00137.x. [DOI] [PubMed] [Google Scholar]
  8. Førre O., Dobloug J. H., Michaelsen T. E., Natvig J. B. Evidence of similar idiotypic determinants on different rheumatoid factor populations. Scand J Immunol. 1979 Mar;9(3):281–289. doi: 10.1111/j.1365-3083.1979.tb02732.x. [DOI] [PubMed] [Google Scholar]
  9. Gold E. R., Fudenberg H. H. Chromic chloride: a coupling reagent for passive hemagglutination reactions. J Immunol. 1967 Nov;99(5):859–866. [PubMed] [Google Scholar]
  10. Iwashita H., Argyrakis A., Lowitzsch K., Spaar F. W. Polyneuropathy in Waldenström's macroglobulinaemia. J Neurol Sci. 1974 Mar;21(3):341–354. doi: 10.1016/0022-510x(74)90178-6. [DOI] [PubMed] [Google Scholar]
  11. Julien J., Vital C., Vallat J. M., Lagueny A., Deminiere C., Darriet D. Polyneuropathy in Waldenström's macroglobulinemia. Deposition of M component on myelin sheaths. Arch Neurol. 1978 Jul;35(7):423–425. doi: 10.1001/archneur.1978.00500310025005. [DOI] [PubMed] [Google Scholar]
  12. Kunkel H. G., Agnello V., Joslin F. G., Winchester R. J., Capra J. D. Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med. 1973 Feb 1;137(2):331–342. doi: 10.1084/jem.137.2.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lampert P. W. Autoimmune and virus-induced demyelinating diseases. A review. Am J Pathol. 1978 Apr;91(1):176–208. [PMC free article] [PubMed] [Google Scholar]
  14. Natvig J. B., Kunkel H. G., Rosenfield R. E., Dalton J. F., Kochwa S. Idiotypic specificities of anti-Rh antibodies. J Immunol. 1976 Jun;116(6):1536–1538. [PubMed] [Google Scholar]
  15. Nyland H., Matre R., Tönder O. Complement receptors in human peripheral nerve tissue. Acta Pathol Microbiol Scand C. 1979 Feb;87C(1):7–10. [PubMed] [Google Scholar]
  16. Plaut A. G., Tomasi T. B., Jr Immunoglobulin M: pentameric Fcmu fragments released by trypsin at higher temperatures. Proc Natl Acad Sci U S A. 1970 Feb;65(2):318–322. doi: 10.1073/pnas.65.2.318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Propp R. P., Means E., Deibel R., Sherer G., Barron K. Waldenström's macroglobulinemia and neuropathy. Deposition of M-component on myelin sheaths. Neurology. 1975 Oct;25(10):980–988. doi: 10.1212/wnl.25.10.980. [DOI] [PubMed] [Google Scholar]
  18. Saida T., Saida K., Silberberg D. H., Brown M. J. Transfer of demyelination by intraneural injection of experimental allergic neuritis serum. Nature. 1978 Apr 13;272(5654):639–641. doi: 10.1038/272639a0. [DOI] [PubMed] [Google Scholar]
  19. Seligmann M., Danon F., Mihaesco C., Fudenberg H. H. Immunoglobulin abnormalities in families of patients with Waldenström's macroglobulinemia. Am J Med. 1967 Jul;43(1):66–83. doi: 10.1016/0002-9343(67)90149-0. [DOI] [PubMed] [Google Scholar]
  20. Willims R. C., Jr, Kunkel H. G., Capra J. D. Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science. 1968 Jul 26;161(3839):379–381. doi: 10.1126/science.161.3839.379. [DOI] [PubMed] [Google Scholar]

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