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. 1981 Jan;67(1):260–263. doi: 10.1172/JCI110021

Genetic analysis of C4 deficiency.

Z L Awdeh, H D Ochs, C A Alper
PMCID: PMC371595  PMID: 7451653

Abstract

The inherited structural polymorphism in the fourth component of complement was studied in the family of a child with homozygous deficiency of this protein. It was shown that a number of family members, including the child's parents, carried a C4 haplotype, C4A*QO C4B*QO, that produced no detectable protein at either the Chido (C4B) or Rodgers (C4A) locus. The family contained individuals with one, two, three, or four expressed C4 genes, and the mean serum C4 levels in such individuals roughly reflected the number of structural genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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