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. 1979 Mar;63(3):437–442. doi: 10.1172/JCI109320

Human C4-binding protein. Association with immune complexes in vitro and in vivo.

J Scharfstein, E B Correa, G R Gallo, V Nussenzweig
PMCID: PMC371971  PMID: 155077

Abstract

C4-binding protein (bp), a glycoprotein with specific binding affinity for the activated form of C4 (C4b), has recently been isolated from human serum and partially characterized. This report demonstrates that C4-bp is incorporated into soluble immune complexes after complement activation in vitro. The reaction requires Ca++ ions and the presence of C4 in serum. Immunopathological studies of various forms of glomerulonephritis revealed intense C4-bp deposition in glomeruli from patients with immune-complex type of pathogenesis. C4-bp deposition was in close correlation with that of C4. These observations, together with the in vitro association of C4-bp to immune complexes, support the notion that the deposits in glomeruli represent the local accumulation of immune complexes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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