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. 1978 Jun;61(6):1498–1507. doi: 10.1172/JCI109070

von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

R R Montgomery, T S Zimmerman
PMCID: PMC372676  PMID: 307007

Abstract

Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose density gradient ultracentrifugation, and crossed immunoelectrophoresis. They show reactions of immunologic nonidentity with each other, and thus, do not share a precursor-product relationship. vWagII is released from normal platelets during blood clotting, accounting for a fourfold higher concentration of vWagII in serum over plasma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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