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. 1978 Jun;61(6):1691–1696. doi: 10.1172/JCI109090

Lithium inhibition of bone mineralization and osteoid formation.

D T Baran, M P Schwartz, M A Bergfeld, S L Teitelbaum, E Slatopolsky, L V Avioli
PMCID: PMC372696  PMID: 659622

Abstract

Lithium chloride administration to growing rats, which resulted in circulating lithium levels of 1.4 meq/liter, was attended by significant suppression of bone mineralization and organic matrix synthesis as assessed by tetracycline labeling and histological quantitation of osteoid, respectively. These effects of lithium were not associated with changes in animal behavior, nor were there any significant differences in blood levels of calcium, phosphorus, alkaline phosphatase, creatinine, pH, or parathyroid hormone. The data suggest that lithium inhibition of bone mineralization is secondary to suppression of osteoid formation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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