Skip to main content
Microbiological Reviews logoLink to Microbiological Reviews
. 1986 Sep;50(3):259–279. doi: 10.1128/mr.50.3.259-279.1986

Philosophy of new drug discovery.

S Omura
PMCID: PMC373071  PMID: 3534537

Full text

PDF
263

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arison B. H., Omura S. Revised structure of cerulenin. J Antibiot (Tokyo) 1974 Jan;27(1):28–30. doi: 10.7164/antibiotics.27.28. [DOI] [PubMed] [Google Scholar]
  2. Aziz M. A., Diallo S., Lariviere M., Diop I. M., Porta I. M., Gaxotte P. Ivermectin in onchocerciasis. Lancet. 1982 Dec 25;2(8313):1456–1457. doi: 10.1016/s0140-6736(82)91350-2. [DOI] [PubMed] [Google Scholar]
  3. Braestrup C., Nielsen M., Olsen C. E. Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2288–2292. doi: 10.1073/pnas.77.4.2288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown A. G., Butterworth D., Cole M., Hanscomb G., Hood J. D., Reading C., Rolinson G. N. Naturally-occurring beta-lactamase inhibitors with antibacterial activity. J Antibiot (Tokyo) 1976 Jun;29(6):668–669. doi: 10.7164/antibiotics.29.668. [DOI] [PubMed] [Google Scholar]
  5. Butterworth D., Cole M., Hanscomb G., Rolinson G. N. Olivanic acids, a family of beta-lactam antibiotics with beta-lactamase inhibitory properties produced by Streptomyces species. I. Detection, properties and fermentation studies. J Antibiot (Tokyo) 1979 Apr;32(4):287–294. doi: 10.7164/antibiotics.32.287. [DOI] [PubMed] [Google Scholar]
  6. Campbell W. C., Benz G. W. Ivermectin: a review of efficacy and safety. J Vet Pharmacol Ther. 1984 Mar;7(1):1–16. doi: 10.1111/j.1365-2885.1984.tb00872.x. [DOI] [PubMed] [Google Scholar]
  7. Greene B. M., Taylor H. R., Cupp E. W., Murphy R. P., White A. T., Aziz M. A., Schulz-Key H., D'Anna S. A., Newland H. S., Goldschmidt L. P. Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. N Engl J Med. 1985 Jul 18;313(3):133–138. doi: 10.1056/NEJM198507183130301. [DOI] [PubMed] [Google Scholar]
  8. Gullo V. P., Zimmerman S. B., Dewey R. S., Hensens O., Cassidy P. J., Oiwa R., Omura S. Factumycin, a new antibiotic (A40A): fermentation, isolation and antibacterial spectrum. J Antibiot (Tokyo) 1982 Dec;35(12):1705–1707. doi: 10.7164/antibiotics.35.1705. [DOI] [PubMed] [Google Scholar]
  9. Hata T., Omura S., Iwai Y., Ono H., Takeshima H. Studies on penicillinase inhibitors produced by microorganisms. J Antibiot (Tokyo) 1972 Aug;25(8):473–474. doi: 10.7164/antibiotics.25.473. [DOI] [PubMed] [Google Scholar]
  10. Hayashi M., Unemoto T., Minami-Kakinuma S., Tanaka H., Omura S. The mode of action of nanaomycins D and A on a gram-negative marine bacterium Vibrio alginolyticus. J Antibiot (Tokyo) 1982 Aug;35(8):1078–1085. doi: 10.7164/antibiotics.35.1078. [DOI] [PubMed] [Google Scholar]
  11. Hopwood D. A., Malpartida F., Kieser H. M., Ikeda H., Duncan J., Fujii I., Rudd B. A., Floss H. G., Omura S. Production of 'hybrid' antibiotics by genetic engineering. Nature. 1985 Apr 18;314(6012):642–644. doi: 10.1038/314642a0. [DOI] [PubMed] [Google Scholar]
  12. Imamura N., Kakinuma K., Ikekawa N., Tanaka H., Omura S. Biosynthesis of vineomycins A1 and B2. J Antibiot (Tokyo) 1982 May;35(5):602–608. doi: 10.7164/antibiotics.35.602. [DOI] [PubMed] [Google Scholar]
  13. Itoh Z., Suzuki T., Nakaya M., Inoue M., Mitsuhashi S. Gastrointestinal motor-stimulating activity of macrolide antibiotics and analysis of their side effects on the canine gut. Antimicrob Agents Chemother. 1984 Dec;26(6):863–869. doi: 10.1128/aac.26.6.863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Iwai Y., Hirano A., Awaya J., Matsuo S., Omura S. 1,3-Diphenethylurea from Streptomyces sp. No. AM-2498. J Antibiot (Tokyo) 1978 Apr;31(4):375–376. doi: 10.7164/antibiotics.31.375. [DOI] [PubMed] [Google Scholar]
  15. Iwai Y., Kimura K., Takahashi Y., Hinotozawa K., Shimizu H., Tanaka H., Omura S. OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties. J Antibiot (Tokyo) 1983 Oct;36(10):1268–1274. doi: 10.7164/antibiotics.36.1268. [DOI] [PubMed] [Google Scholar]
  16. Iwai Y., Kora A., Takahashi Y., Hayashi T., Awaya J., Masuma R., Oiwa R., Omura S. Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867. J Antibiot (Tokyo) 1978 Oct;31(10):959–965. doi: 10.7164/antibiotics.31.959. [DOI] [PubMed] [Google Scholar]
  17. Kasai M., Shirahata K., Ishii S., Mineura K., Marumo H., Tanaka H., Omura S. Structure of nanaomycin E, a new nanaomycin. J Antibiot (Tokyo) 1979 May;32(5):442–445. doi: 10.7164/antibiotics.32.442. [DOI] [PubMed] [Google Scholar]
  18. Kawaguchi A., Tomoda H., Okuda S., Awaya J., Omura S. Cerulenin resistance in a cerulenin-producing fungus. Isolation of cerulenin insensitive fatty acid synthetase. Arch Biochem Biophys. 1979 Oct 1;197(1):30–35. doi: 10.1016/0003-9861(79)90214-5. [DOI] [PubMed] [Google Scholar]
  19. Kitaura K., Araki Y., Marumo H. [The therapeutic effect of nanaomycin A against experimental Trichophyton mentagrophytes infection in guinea pigs (author's transl)]. Jpn J Antibiot. 1980 Jul;33(7):728–732. [PubMed] [Google Scholar]
  20. Konda Y., Suzuki Y., Omura S., Onda M. Alkaloid from Thermoactinomyces species. Chem Pharm Bull (Tokyo) 1976 Jan;24(1):92–96. doi: 10.1248/cpb.24.92. [DOI] [PubMed] [Google Scholar]
  21. Kresze G. B., Steber L., Oesterhelt D., Lynen F. Reaction of yeast fatty acid synthetase with iodoacetamide. 2. Identification of the amino acid residues reacting with iodoacetamide and primary structure of a peptide containing the peripheral sulfhydryl group. Eur J Biochem. 1977 Sep 15;79(1):181–190. doi: 10.1111/j.1432-1033.1977.tb11796.x. [DOI] [PubMed] [Google Scholar]
  22. Lariviere M., Vingtain P., Aziz M., Beauvais B., Weimann D., Derouin F., Ginoux J., Schulz-Key H., Gaxotte P., Basset D. Double-blind study of ivermectin and diethylcarbamazine in African onchocerciasis patients with ocular involvement. Lancet. 1985 Jul 27;2(8448):174–177. doi: 10.1016/s0140-6736(85)91496-5. [DOI] [PubMed] [Google Scholar]
  23. Matsuyama K., Takahashi Y., Yamashita M., Hirano A., Omura S. 2'-Amino-2'-deoxyadenosine produced by a strain of Actinomadura. J Antibiot (Tokyo) 1979 Dec;32(12):1367–1369. doi: 10.7164/antibiotics.32.1367. [DOI] [PubMed] [Google Scholar]
  24. Murata M., Miyasaka T., Tanaka H., Omura S. Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase. J Antibiot (Tokyo) 1985 Aug;38(8):1025–1033. doi: 10.7164/antibiotics.38.1025. [DOI] [PubMed] [Google Scholar]
  25. Nakagawa A., Iwai Y., Hashimoto H., Miyazaki N., Oiwa R., Takahashi Y., Hirano A., Shibukawa N., Kojima Y., Omura S. Virantmycin, a new antiviral antibiotic produced by a strain of Streptomyces. J Antibiot (Tokyo) 1981 Nov;34(11):1408–1415. doi: 10.7164/antibiotics.34.1408. [DOI] [PubMed] [Google Scholar]
  26. Nakagawa A., Tomoda H., Hao M. V., Okano K., Iwai Y., Omura S. Antiviral activities of pentalenolactones. J Antibiot (Tokyo) 1985 Aug;38(8):1114–1115. doi: 10.7164/antibiotics.38.1114. [DOI] [PubMed] [Google Scholar]
  27. Nishikiori T., Masuma R., Oiwa R., Katagiri M., Awaya J., Iwai Y., Omura S. Aurantinin, a new antibiotic of bacterial origin. J Antibiot (Tokyo) 1978 Jun;31(6):525–532. doi: 10.7164/antibiotics.31.525. [DOI] [PubMed] [Google Scholar]
  28. Oiwa R., Iwai Y., Takahashi Y., Kitao K., Omura S. Taxonomic studies of a stubomycin--(hitachimycin)--producing actinomycete. Kitasato Arch Exp Med. 1982 Dec;55(3-4):119–124. [PubMed] [Google Scholar]
  29. Oiwa R., Katagiri M., Tanaka N., Takahashi Y., Sato K. A new peptide antibiotic KM-8. J Antibiot (Tokyo) 1975 Oct;28(10):819–820. doi: 10.7164/antibiotics.28.819. [DOI] [PubMed] [Google Scholar]
  30. Okazaki H., Ohta K., Kanamaru T., Ishimaru T., Kishi T. A potent prolyl hydroxylase inhibitor, P-1894B, produced by a strain of Streptomyces. J Antibiot (Tokyo) 1981 Oct;34(10):1355–1356. doi: 10.7164/antibiotics.34.1355. [DOI] [PubMed] [Google Scholar]
  31. Okubo S., Morimoto M., Mineura K., Marumo H., Omura S. Studies on antitumor activity of prumycin. IV. Effect of prumycin on mouse immune system. J Antibiot (Tokyo) 1980 Feb;33(2):231–235. doi: 10.7164/antibiotics.33.231. [DOI] [PubMed] [Google Scholar]
  32. Okubo S., Nakamura N., Ito K., Marumo H., Tanaka M., Omura S. Antitumor activity of prumycin. J Antibiot (Tokyo) 1979 Apr;32(4):347–354. doi: 10.7164/antibiotics.32.347. [DOI] [PubMed] [Google Scholar]
  33. Omura S. Cerulenin. Methods Enzymol. 1981;72:520–532. [PubMed] [Google Scholar]
  34. Omura S., Hinotozawa K., Imamura N., Murata M. The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin. J Antibiot (Tokyo) 1984 Aug;37(8):939–940. doi: 10.7164/antibiotics.37.939. [DOI] [PubMed] [Google Scholar]
  35. Omura S., Hirano A., Iwai Y., Masuma R. Herquline, a new alkaloid produced by Penicillium herquei. Fermentation, isolation and properties. J Antibiot (Tokyo) 1979 Aug;32(8):786–790. doi: 10.7164/antibiotics.32.786. [DOI] [PubMed] [Google Scholar]
  36. Omura S., Imai H., Takeshima H., Nakagawa A. Structure of a new antimicrobial unsaturated fatty acid from Sm. kitasatoenis NU-23-1. Chem Pharm Bull (Tokyo) 1976 Dec;24(12):3139–3143. doi: 10.1248/cpb.24.3139. [DOI] [PubMed] [Google Scholar]
  37. Omura S., Imamura N., Hinotozawa K., Otoguro K., Lukacs G., Faghih R., Tolmann R., Arison B. H., Smith J. L. The structure of virustomycin A. J Antibiot (Tokyo) 1983 Dec;36(12):1783–1786. doi: 10.7164/antibiotics.36.1783. [DOI] [PubMed] [Google Scholar]
  38. Omura S., Imamura N., Kuga H., Ishikawa H., Yamazaki Y., Okano K., Kimura K., Takahashi Y., Tanaka H. Adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties. J Antibiot (Tokyo) 1985 Aug;38(8):1008–1015. doi: 10.7164/antibiotics.38.1008. [DOI] [PubMed] [Google Scholar]
  39. Omura S., Iwai Y., Hinotozawa K., Takahashi Y., Kato J., Nakagawa A., Hirano A., Shimizu H., Haneda K. Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov. J Antibiot (Tokyo) 1982 Jun;35(6):645–652. doi: 10.7164/antibiotics.35.645. [DOI] [PubMed] [Google Scholar]
  40. Omura S., Iwai Y., Hinotozawa K., Tanaka H., Takahashi Y., Nakagawa A. OM-704 A, a new antibiotic active against gram-positive bacteria produced by Streptomyces sp. J Antibiot (Tokyo) 1982 Nov;35(11):1425–1429. doi: 10.7164/antibiotics.35.1425. [DOI] [PubMed] [Google Scholar]
  41. Omura S., Iwai Y., Masuma R., Hayashi M., Furusato T., Takagaki T. A new peptide antibiotic, alboleutin. J Antibiot (Tokyo) 1980 Jul;33(7):758–759. doi: 10.7164/antibiotics.33.758. [DOI] [PubMed] [Google Scholar]
  42. Omura S., Iwai Y., Nakagawa A., Iwata R., Takahashi Y., Shimizu H., Tanaka H. Thiotetromycin, a new antibiotic. Taxonomy, production, isolation, and physicochemical and biological properties. J Antibiot (Tokyo) 1983 Feb;36(2):109–114. doi: 10.7164/antibiotics.36.109. [DOI] [PubMed] [Google Scholar]
  43. Omura S., Iwai Y., Suzuki Y., Awaya J., Konda Y. Production of quinoline-2-methanol and quinoline-2-methanol acetate by a new species of Kitasatoa Kitasato griseophaeus. J Antibiot (Tokyo) 1976 Aug;29(8):797–803. doi: 10.7164/antibiotics.29.797. [DOI] [PubMed] [Google Scholar]
  44. Omura S., Iwata R., Iwai Y., Taga S., Tanaka Y., Tomoda H. Luminamicin, a new antibiotic. Production, isolation and physico-chemical and biological properties. J Antibiot (Tokyo) 1985 Oct;38(10):1322–1326. doi: 10.7164/antibiotics.38.1322. [DOI] [PubMed] [Google Scholar]
  45. Omura S., Katagiri M., Atsumi K., Hata T., Jakubowski A. A., Springs E. B., Tishler M. Structure of prumycin. J Chem Soc Perkin 1. 1974;0(14):1627–1631. doi: 10.1039/p19740001627. [DOI] [PubMed] [Google Scholar]
  46. Omura S., Katagiri M., Hata T. The structures of leucomycin A4A5A6A7A8 and A9. J Antibiot (Tokyo) 1967 Jul;20(4):234–235. [PubMed] [Google Scholar]
  47. Omura S., Kitao C., Tanaka H., Oiwa R., Takahashi Y. A new antibiotic,, asukamycin, produced by Streptomyces. J Antibiot (Tokyo) 1976 Sep;29(9):876–881. doi: 10.7164/antibiotics.29.876. [DOI] [PubMed] [Google Scholar]
  48. Omura S., Mamada H., Wang N. J., Imamura N., Oiwa R., Iwai Y., Muto N. Takaokamycin, a new peptide antibiotic produced by Streptomyces sp. J Antibiot (Tokyo) 1984 Jul;37(7):700–705. doi: 10.7164/antibiotics.37.700. [DOI] [PubMed] [Google Scholar]
  49. Omura S., Miyano K., Nakagawa A., Sano H., Komiyama K., Umezawa I., Shibata K., Satsumabayashi S. Chemical modification and antitumor activity of herbimycin A. 8,9-Epoxide, 7,9-cyclic carbamate, and 17 or 19-amino derivatives. J Antibiot (Tokyo) 1984 Oct;37(10):1264–1267. doi: 10.7164/antibiotics.37.1264. [DOI] [PubMed] [Google Scholar]
  50. Omura S., Murata M., Hanaki H., Hinotozawa K., Oiwa R., Tanaka H. Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action. J Antibiot (Tokyo) 1984 Aug;37(8):829–835. doi: 10.7164/antibiotics.37.829. [DOI] [PubMed] [Google Scholar]
  51. Omura S., Murata M., Imamura N., Iwai Y., Tanaka H., Furusaki A., Matsumoto H. Oxetin, a new antimetabolite from an actinomycete. Fermentation, isolation, structure and biological activity. J Antibiot (Tokyo) 1984 Nov;37(11):1324–1332. doi: 10.7164/antibiotics.37.1324. [DOI] [PubMed] [Google Scholar]
  52. Omura S., Nakagawa A., Aoyama H., Iwai Y., Kuwahara M., Furusato T. Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete. J Antibiot (Tokyo) 1983 Sep;36(9):1129–1135. doi: 10.7164/antibiotics.36.1129. [DOI] [PubMed] [Google Scholar]
  53. Omura S., Nakagawa A., Iwata R., Hatano A. Structure of a new antibacterial antibiotic, thiotetromycin. J Antibiot (Tokyo) 1983 Dec;36(12):1781–1782. doi: 10.7164/antibiotics.36.1781. [DOI] [PubMed] [Google Scholar]
  54. Omura S., Otoguro K., Nishikiori T., Oiwa R., Iwai Y. Setamycin, a new antibiotic. J Antibiot (Tokyo) 1981 Oct;34(10):1253–1256. doi: 10.7164/antibiotics.34.1253. [DOI] [PubMed] [Google Scholar]
  55. Omura S., Sadakane N., Tanaka Y., Matsubara H. Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis. J Antibiot (Tokyo) 1983 Jul;36(7):927–930. doi: 10.7164/antibiotics.36.927. [DOI] [PubMed] [Google Scholar]
  56. Omura S., Sano H., Sunazuka T. Structure activity relationships of spiramycins. J Antimicrob Chemother. 1985 Jul;16 (Suppl A):1–11. doi: 10.1093/jac/16.suppl_a.1. [DOI] [PubMed] [Google Scholar]
  57. Omura S., Shimizu H., Iwai Y., Hinotozawa K., Otoguro K., Hashimoto H., Nakagawa A. AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces. J Antibiot (Tokyo) 1982 Dec;35(12):1632–1637. doi: 10.7164/antibiotics.35.1632. [DOI] [PubMed] [Google Scholar]
  58. Omura S., Tanaka H., Iwai Y., Nishigaki K., Awaya J., Takahashi Y., Masuma R. A new antibiotic, setomimycin, produced by a strain of Streptomyces. J Antibiot (Tokyo) 1978 Nov;31(11):1091–1098. doi: 10.7164/antibiotics.31.1091. [DOI] [PubMed] [Google Scholar]
  59. Omura S., Tanaka H., Oiwa R., Awaya J., Masuma R., Tanaka K. New antitumor antibiotics, OS-4742 A1, A2, B1 and B2 produced by a strain of Streptomyces. J Antibiot (Tokyo) 1977 Nov;30(11):908–916. doi: 10.7164/antibiotics.30.908. [DOI] [PubMed] [Google Scholar]
  60. Omura S., Tanaka H., Oiwa R., Nagai T., Koyama Y., Takahashi Y. Studies on bacterial cell wall inhibitors. VI. Screening method for the specific inhibitors of peptidoglycan synthesis. J Antibiot (Tokyo) 1979 Oct;32(10):978–984. doi: 10.7164/antibiotics.32.978. [DOI] [PubMed] [Google Scholar]
  61. Omura S., Tanaka H., Tanaka Y., Spiri-Nakagawa P., Oiwa R., Takahashi Y., Matsuyama K., Iwai Y. Studies on bacterial cell wall inhibitors. VII. Azureomycins A and B, new antibiotics produced by Pseudonocardia azurea nov. sp. Taxonomy of the producing organism, isolation, characterization and biological properties. J Antibiot (Tokyo) 1979 Oct;32(10):985–994. doi: 10.7164/antibiotics.32.985. [DOI] [PubMed] [Google Scholar]
  62. Omura S., Tanaka Y., Kitao C., Tanaka H., Iwai Y. Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation. Antimicrob Agents Chemother. 1980 Nov;18(5):691–695. doi: 10.1128/aac.18.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Omura S., Tanaka Y., Mamada H., Masuma R. Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. J Antibiot (Tokyo) 1984 May;37(5):494–502. doi: 10.7164/antibiotics.37.494. [DOI] [PubMed] [Google Scholar]
  64. Omura S., Tanaka Y., Nakagawa A., Iwai Y., Inoue M., Tanaka H. Irumamycin, a new antibiotic active against phytopathogenic fungi. J Antibiot (Tokyo) 1982 Feb;35(2):256–257. doi: 10.7164/antibiotics.35.256. [DOI] [PubMed] [Google Scholar]
  65. Omura S., Tanaka Y., Takahashi Y., Chia I., Inoue M., Iwai Y. Irumamycin, an antifungal 20-membered macrolide produced by a Streptomyces. Taxonomy, fermentation and biological properties. J Antibiot (Tokyo) 1984 Dec;37(12):1572–1578. doi: 10.7164/antibiotics.37.1572. [DOI] [PubMed] [Google Scholar]
  66. Omura S., Tsuzuki K., Iwai Y., Kishi M., Watanabe S., Shimizu H. Anticoccidial activity of frenolicin B and its derivatives. J Antibiot (Tokyo) 1985 Oct;38(10):1447–1448. doi: 10.7164/antibiotics.38.1447. [DOI] [PubMed] [Google Scholar]
  67. Omura S., Tsuzuki K., Nakagawa A., Lukacs G. Biosynthetic origin of carbons 3 and 4 of leucomycin aglycone. J Antibiot (Tokyo) 1983 May;36(5):611–613. doi: 10.7164/antibiotics.36.611. [DOI] [PubMed] [Google Scholar]
  68. Omura S., Tsuzuki K., Sunazuka T., Toyota H., Takahashi I., Itoh Z. Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship. J Antibiot (Tokyo) 1985 Nov;38(11):1631–1632. doi: 10.7164/antibiotics.38.1631. [DOI] [PubMed] [Google Scholar]
  69. Omura S., Tsuzuki K., Tanaka Y., Sakakibara H., Aizawa M., Lukacs G. Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone. J Antibiot (Tokyo) 1983 May;36(5):614–616. doi: 10.7164/antibiotics.36.614. [DOI] [PubMed] [Google Scholar]
  70. Onda M., Konda Y., Narimatsu Y., Tanaka H., Awaya J. Letter: Revised structure for an alkaloid fron Streptomyces sp. NA-337. Chem Pharm Bull (Tokyo) 1975 Oct;23(10):2462–2463. doi: 10.1248/cpb.23.2462. [DOI] [PubMed] [Google Scholar]
  71. Ono H., Matsumae A., Iwai Y., Nakae M., Omura S. In vitro and in vivo activity of penicillinase inhibitor KA-107 against Staphylococcus aureus FS-1277. Antimicrob Agents Chemother. 1973 Sep;4(3):226–230. doi: 10.1128/aac.4.3.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Sadakane N., Tanaka Y., Omura S. Hybrid biosynthesis of a new macrolide antibiotic by a daunomycin-producing microorganism. J Antibiot (Tokyo) 1983 Jul;36(7):921–922. doi: 10.7164/antibiotics.36.921. [DOI] [PubMed] [Google Scholar]
  73. Sadakane N., Tanaka Y., Omura S. Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms. J Antibiot (Tokyo) 1982 Jun;35(6):680–687. doi: 10.7164/antibiotics.35.680. [DOI] [PubMed] [Google Scholar]
  74. Sadakane N., Tanaka Y., Omura S. New 20-membered lactones, irumanolides I and II, produced by a mutant of Streptomyces. J Antibiot (Tokyo) 1983 Jul;36(7):931–933. doi: 10.7164/antibiotics.36.931. [DOI] [PubMed] [Google Scholar]
  75. Sakakibara H., Okekawa O., Fujiwara T., Otani M., Omura S. Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q). J Antibiot (Tokyo) 1981 Aug;34(8):1001–1010. doi: 10.7164/antibiotics.34.1001. [DOI] [PubMed] [Google Scholar]
  76. Sato T., Yamaguchi K., Katagiri M., Awaya J., Iwai Y. Studies on antibiotic O-2867, a new antiobiotic. J Antibiot (Tokyo) 1971 Nov;24(11):774–778. doi: 10.7164/antibiotics.24.774. [DOI] [PubMed] [Google Scholar]
  77. Sato Y., Nomura S., Kamio Y., Omura S., Hata T. Studies on cerulenin, 3. Isolation and physico-chemical properties of cerulenin. J Antibiot (Tokyo) 1967 Nov;20(6):344–348. [PubMed] [Google Scholar]
  78. Satoh K., Komiyama K., Kitao C., Iwai Y., Atsumi K. Isolation and characterization of a new antitumor antibiotic OS-3256-B from Streptomyces candidus var. azaticus. J Antibiot (Tokyo) 1974 Aug;27(8):620–625. doi: 10.7164/antibiotics.27.620. [DOI] [PubMed] [Google Scholar]
  79. Schwartz J. L., Katagiri M., Omura S., Tishler M. The mechanism of prumycin action. J Antibiot (Tokyo) 1974 Jun;27(6):379–385. doi: 10.7164/antibiotics.27.379. [DOI] [PubMed] [Google Scholar]
  80. Shen Y. Q., Heim J., Solomon N. A., Wolfe S., Demain A. L. Repression of beta-lactam production in Cephalosporium acremonium by nitrogen sources. J Antibiot (Tokyo) 1984 May;37(5):503–511. doi: 10.7164/antibiotics.37.503. [DOI] [PubMed] [Google Scholar]
  81. Spiri-Nakagawa P., Oiwa R., Tanaka Y., Tanaka H., Omura S. The site of inhibition of bacterial cell wall peptidoglycan synthesis by azureomycin B, a new antibiotic. J Biochem. 1980 Aug;88(2):565–570. doi: 10.1093/oxfordjournals.jbchem.a133004. [DOI] [PubMed] [Google Scholar]
  82. Spratt B. G., Jobanputra V., Zimmermann W. Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12. Antimicrob Agents Chemother. 1977 Sep;12(3):406–409. doi: 10.1128/aac.12.3.406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Tanaka H., Koyama Y., Awaya J., Marumo H., Oiwa R. Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties. J Antibiot (Tokyo) 1975 Nov;28(11):860–867. doi: 10.7164/antibiotics.28.860. [DOI] [PubMed] [Google Scholar]
  84. Tanaka H., Minami-Kakinuma S., Omura S. Biosynthesis of nanaomycin. III. Nanaomycin A formation from nanaomycin D by nanaomycin D reductase via a hydroquinone. J Antibiot (Tokyo) 1982 Nov;35(11):1565–1570. doi: 10.7164/antibiotics.35.1565. [DOI] [PubMed] [Google Scholar]
  85. Tomoda H., Kawaguchi A., Yasuhara T., Nakajima T., Omura S., Okuda S. Cerulenin resistance in a cerulenin-producing fungus. III. Studies on active-site peptides of fatty acid synthetase from Cephalosporium caerulens. J Biochem. 1984 Jun;95(6):1712–1723. [PubMed] [Google Scholar]
  86. Umezawa I., Komiyama K., Takeshima H., Awaya J., Omura S. A new antitumor antibiotic, PO-357. J Antibiot (Tokyo) 1976 Nov;29(11):1249–1251. doi: 10.7164/antibiotics.29.1249. [DOI] [PubMed] [Google Scholar]
  87. Umezawa I., Takeshima H., Komiyama K., Koh Y., Yamamoto H., Kawaguchi M. A new antitumor antibiotic, stubomycin. J Antibiot (Tokyo) 1981 Mar;34(3):259–265. doi: 10.7164/antibiotics.34.259. [DOI] [PubMed] [Google Scholar]
  88. Vance D., Goldberg I., Mitsuhashi O., Bloch K. Inhibition of fatty acid synthetases by the antibiotic cerulenin. Biochem Biophys Res Commun. 1972 Aug 7;48(3):649–656. doi: 10.1016/0006-291x(72)90397-x. [DOI] [PubMed] [Google Scholar]
  89. Wolfrom M. L., Winkley M. W. Anomeric purine nucleosides of the furanose form of 2-amino-2-deoxy-D-ribose. J Org Chem. 1967 Jun;32(6):1823–1825. doi: 10.1021/jo01281a026. [DOI] [PubMed] [Google Scholar]

Articles from Microbiological Reviews are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES