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. 1987 Sep;51(3):341–350. doi: 10.1128/mr.51.3.341-350.1987

Mechanism of bactericidal action of aminoglycosides.

B D Davis
PMCID: PMC373115  PMID: 3312985

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Selected References

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  1. ANAND N., DAVIS B. D., ARMITAGE A. K. Uptake of streptomycin by Escherichia coli. Nature. 1960 Jan 2;185:23–24. doi: 10.1038/185023a0. [DOI] [PubMed] [Google Scholar]
  2. Ahmad M. H., Rechenmacher A., Böck A. Interaction between aminoglycoside uptake and ribosomal resistance mutations. Antimicrob Agents Chemother. 1980 Nov;18(5):798–806. doi: 10.1128/aac.18.5.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anderson P., Davies J., Davis B. D. Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli. J Mol Biol. 1967 Oct 14;29(1):203–215. doi: 10.1016/0022-2836(67)90191-x. [DOI] [PubMed] [Google Scholar]
  4. Andry K., Bockrath R. C. Dihydrostreptomycin accumulation in E. coli. Nature. 1974 Oct 11;251(5475):534–536. doi: 10.1038/251534a0. [DOI] [PubMed] [Google Scholar]
  5. Bassford P. J., Jr, Silhavy T. J., Beckwith J. R. Use of gene fusion to study secretion of maltose-binding protein into Escherichia coli periplasm. J Bacteriol. 1979 Jul;139(1):19–31. doi: 10.1128/jb.139.1.19-31.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Biswas D. K., Gorini L. The attachment site of streptomycin to the 30S ribosomal subunit. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2141–2144. doi: 10.1073/pnas.69.8.2141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bryan L. E., Kwan S. Roles of ribosomal binding, membrane potential, and electron transport in bacterial uptake of streptomycin and gentamicin. Antimicrob Agents Chemother. 1983 Jun;23(6):835–845. doi: 10.1128/aac.23.6.835. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bryan L. E., Van Den Elzen H. M. Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria. Antimicrob Agents Chemother. 1977 Aug;12(2):163–177. doi: 10.1128/aac.12.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bryan L. E., Van den Elzen H. M. Streptomycin accumulation in susceptible and resistant strains of Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1976 Jun;9(6):928–938. doi: 10.1128/aac.9.6.928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Böck A., Petzet A., Piepersberg W. Ribosomal ambiguity (ram) mutations facilitate diyhydrostreptomycin binding to ribosomes. FEBS Lett. 1979 Aug 15;104(2):317–321. doi: 10.1016/0014-5793(79)80842-x. [DOI] [PubMed] [Google Scholar]
  11. Campbell B. D., Kadner R. J. Relation of aerobiosis and ionic strength to the uptake of dihydrostreptomycin in Escherichia coli. Biochim Biophys Acta. 1980 Nov 5;593(1):1–10. doi: 10.1016/0005-2728(80)90002-x. [DOI] [PubMed] [Google Scholar]
  12. Chang F. N., Flaks J. G. Binding of dihydrostreptomycin to Escherichia coli ribosomes: characteristics and equilibrium of the reaction. Antimicrob Agents Chemother. 1972 Oct;2(4):294–307. doi: 10.1128/aac.2.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Cozzone A., Donini P. Turnover of polysomes in amino acid-starved Escherichia coli. J Mol Biol. 1973 May 5;76(1):149–162. doi: 10.1016/0022-2836(73)90086-7. [DOI] [PubMed] [Google Scholar]
  14. DAVIES J., GILBERT W., GORINI L. STREPTOMYCIN, SUPPRESSION, AND THE CODE. Proc Natl Acad Sci U S A. 1964 May;51:883–890. doi: 10.1073/pnas.51.5.883. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. DUBIN D. T., DAVIS B. D. The effect of streptomycin on potassium flux in Escherichia coli. Biochim Biophys Acta. 1961 Sep 16;52:400–402. doi: 10.1016/0006-3002(61)90697-7. [DOI] [PubMed] [Google Scholar]
  16. DUBIN D. T., HANCOCK R., DAVIS B. D. THE SEQUENCE OF SOME EFFECTS OF STREPTOMYCIN IN ESCHERICHIA COLI. Biochim Biophys Acta. 1963 Aug 13;74:476–489. doi: 10.1016/0006-3002(63)91390-8. [DOI] [PubMed] [Google Scholar]
  17. Damper P. D., Epstein W. Role of the membrane potential in bacterial resistance to aminoglycoside antibiotics. Antimicrob Agents Chemother. 1981 Dec;20(6):803–808. doi: 10.1128/aac.20.6.803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Davis B. D., Chen L. L., Tai P. C. Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proc Natl Acad Sci U S A. 1986 Aug;83(16):6164–6168. doi: 10.1073/pnas.83.16.6164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Davis B. D., Tai P. C. The mechanism of protein secretion across membranes. Nature. 1980 Jan 31;283(5746):433–438. doi: 10.1038/283433a0. [DOI] [PubMed] [Google Scholar]
  20. ERDOS T., ULLMANN A. Effect of streptomycin on the incorporation of amino-acids labelled with carbon-14 into ribonucleic acid and protein in a cell-free system of a Mycobacterium. Nature. 1959 Feb 28;183(4661):618–619. doi: 10.1038/183618a0. [DOI] [PubMed] [Google Scholar]
  21. Eisenberg E. S., Mandel L. J., Kaback H. R., Miller M. H. Quantitative association between electrical potential across the cytoplasmic membrane and early gentamicin uptake and killing in Staphylococcus aureus. J Bacteriol. 1984 Mar;157(3):863–867. doi: 10.1128/jb.157.3.863-867.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. FLAKS J. G., COX E. C., WITTING M. L., WHITE J. R. Polypeptide synthesis with ribosomes from streptomycin-resistant and dependent E. coli. Biochem Biophys Res Commun. 1962 May 11;7:390–393. doi: 10.1016/0006-291x(62)90321-2. [DOI] [PubMed] [Google Scholar]
  23. GORINI L., KATAJA E. PHENOTYPIC REPAIR BY STREPTOMYCIN OF DEFECTIVE GENOTYPES IN E. COLI. Proc Natl Acad Sci U S A. 1964 Mar;51:487–493. doi: 10.1073/pnas.51.3.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. HANCOCK R. EARLY EFFECTS OF STREPTOMYCIN ON BACILLUS MEGATERIUM. J Bacteriol. 1964 Sep;88:633–639. doi: 10.1128/jb.88.3.633-639.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. HURWITZ C., ROSANO C. L. Accumulation of label from C14-streptomycin by Escherichia coli. J Bacteriol. 1962 Jun;83:1193–1201. doi: 10.1128/jb.83.6.1193-1201.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Hancock R. E. Aminoglycoside uptake and mode of action--with special reference to streptomycin and gentamicin. I. Antagonists and mutants. J Antimicrob Chemother. 1981 Oct;8(4):249–276. doi: 10.1093/jac/8.4.249. [DOI] [PubMed] [Google Scholar]
  27. Hancock R. E. Aminoglycoside uptake and mode of action-with special reference to streptomycin and gentamicin. II. Effects of aminoglycosides on cells. J Antimicrob Chemother. 1981 Dec;8(6):429–445. doi: 10.1093/jac/8.6.429. [DOI] [PubMed] [Google Scholar]
  28. Hengge R., Boos W. Defective secretion of maltose- and ribose-binding proteins caused by a truncated periplasmic protein in Escherichia coli. J Bacteriol. 1985 Jun;162(3):972–978. doi: 10.1128/jb.162.3.972-978.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hummel H., Ahmad M. H., Böck A. On the basis of aminoglycoside-dependent growth of mutants of Escherichia coli: in vitro studies and the model. Mol Gen Genet. 1983;191(2):176–181. doi: 10.1007/BF00334810. [DOI] [PubMed] [Google Scholar]
  30. Hurwitz C., Braun C. B., Rosano C. L. Role of ribosome recycling in uptake of dihydrostreptomycin by sensitive and resistant Escherichia coli. Biochim Biophys Acta. 1981 Jan 29;652(1):168–176. doi: 10.1016/0005-2787(81)90220-3. [DOI] [PubMed] [Google Scholar]
  31. Höltje J. V. Induction of streptomycin uptake in resistant strains of Escherichia coli. Antimicrob Agents Chemother. 1979 Feb;15(2):177–181. doi: 10.1128/aac.15.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Höltje J. V. Streptomycin uptake via an inducible polyamine transport system in Escherichia coli. Eur J Biochem. 1978 May 16;86(2):345–351. doi: 10.1111/j.1432-1033.1978.tb12316.x. [DOI] [PubMed] [Google Scholar]
  33. Ito K., Beckwith J. R. Role of the mature protein sequence of maltose-binding protein in its secretion across the E. coli cytoplasmic membrane. Cell. 1981 Jul;25(1):143–150. doi: 10.1016/0092-8674(81)90238-5. [DOI] [PubMed] [Google Scholar]
  34. JEWETZ E., GUNNISON J. B., BRUFF J. B., COLEMAN V. R. Studies on antibiotic synergism and antagonism. Synergism among seven antibiotics against various bacteria in vitro. J Bacteriol. 1952 Jul;64(1):29–39. doi: 10.1128/jb.64.1.29-39.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. KOGUT M., LIGHTBROWN J. W., ISAACSON P. STREPTOMYCIN ACTION AND ANAEROBIOSIS. J Gen Microbiol. 1965 May;39:155–164. doi: 10.1099/00221287-39-2-155. [DOI] [PubMed] [Google Scholar]
  36. KURLAND C. G., NOMURA M., WATSON J. D. The physical properties of the chloromycetin particles. J Mol Biol. 1962 May;4:388–394. doi: 10.1016/s0022-2836(62)80019-9. [DOI] [PubMed] [Google Scholar]
  37. Koshland D., Botstein D. Evidence for posttranslational translocation of beta-lactamase across the bacterial inner membrane. Cell. 1982 Oct;30(3):893–902. doi: 10.1016/0092-8674(82)90294-x. [DOI] [PubMed] [Google Scholar]
  38. LEDERBERG J. Streptomycin resistance; a genetically recessive mutation. J Bacteriol. 1951 May;61(5):549–550. doi: 10.1128/jb.61.5.549-550.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Lelong J. C., Gros D., Cousin M. A., Grunberg-Manago M., Gros F. Streptomycin induced release of fMet-tRNA from the ribosomal initiation complex. Biochem Biophys Res Commun. 1971 Feb 5;42(3):530–537. doi: 10.1016/0006-291x(71)90403-7. [DOI] [PubMed] [Google Scholar]
  40. MAGER J., BENEDICT M., ARTMAN M. A common site of action of polyamines and streptomycin. Biochim Biophys Acta. 1962 Jul 30;62:202–204. doi: 10.1016/0006-3002(62)90519-x. [DOI] [PubMed] [Google Scholar]
  41. Mates S. M., Eisenberg E. S., Mandel L. J., Patel L., Kaback H. R., Miller M. H. Membrane potential and gentamicin uptake in Staphylococcus aureus. Proc Natl Acad Sci U S A. 1982 Nov;79(21):6693–6697. doi: 10.1073/pnas.79.21.6693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Mates S. M., Patel L., Kaback H. R., Miller M. H. Membrane potential in anaerobically growing Staphylococcus aureus and its relationship to gentamicin uptake. Antimicrob Agents Chemother. 1983 Apr;23(4):526–530. doi: 10.1128/aac.23.4.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Modolell J., Davis B. D. Breakdown by streptomycin of initiation complexes formed on ribosomes of Escherichia coli. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1148–1155. doi: 10.1073/pnas.67.3.1148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Moellering R. C., Jr, Weinberg A. N. Studies on antibiotic syngerism against enterococci. II. Effect of various antibiotics on the uptake of 14 C-labeled streptomycin by enterococci. J Clin Invest. 1971 Dec;50(12):2580–2584. doi: 10.1172/JCI106758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Muir M. E., Ballesteros M., Wallace B. J. Respiration rate, growth rate and the accumulation of streptomycin in Escherichia coli. J Gen Microbiol. 1985 Oct;131(10):2573–2579. doi: 10.1099/00221287-131-10-2573. [DOI] [PubMed] [Google Scholar]
  46. Muir M. E., Wallace B. J. Isolation of mutants of Escherichia coli uncoupled in oxidative phosphorylation using hypersensitivity to streptomycin. Biochim Biophys Acta. 1979 Aug 14;547(2):218–229. doi: 10.1016/0005-2728(79)90005-7. [DOI] [PubMed] [Google Scholar]
  47. Muir M. E., van Heeswyck R. S., Wallace B. J. Effect of growth rate on streptomycin accumulation by Escherichia coli and Bacillus megaterium. J Gen Microbiol. 1984 Aug;130(8):2015–2022. doi: 10.1099/00221287-130-8-2015. [DOI] [PubMed] [Google Scholar]
  48. Nichols W. W., Young S. N. Respiration-dependent uptake of dihydrostreptomycin by Escherichia coli. Its irreversible nature and lack of evidence for a uniport process. Biochem J. 1985 Jun 1;228(2):505–512. doi: 10.1042/bj2280505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. PLOTZ P. H., DAVIS B. D. Absence of a chloramphenicol-insensitive phase of streptomycin action. J Bacteriol. 1962 Apr;83:802–805. doi: 10.1128/jb.83.4.802-805.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. PLOTZ P. H., DAVIS B. D. Synergism between streptomycin and penicillin: a proposed mechanism. Science. 1962 Mar 23;135(3508):1067–1068. doi: 10.1126/science.135.3508.1067. [DOI] [PubMed] [Google Scholar]
  51. PLOTZ P. H., DUBIN D. T., DAVIS B. D. Influence of salts on the uptake of streptomycin by Escherichia coli. Nature. 1961 Sep 23;191:1324–1325. doi: 10.1038/1911324a0. [DOI] [PubMed] [Google Scholar]
  52. Prouty W. F., Karnovsky M. J., Goldberg A. L. Degradation of abnormal proteins in Escherichia coli. Formation of protein inclusions in cells exposed to amino acid analogs. J Biol Chem. 1975 Feb 10;250(3):1112–1122. [PubMed] [Google Scholar]
  53. ROTH H., AMOS H., DAVIS B. D. Purine nucleotide excretion by Escherichia coli in the presence of streptomycin. Biochim Biophys Acta. 1960 Jan 29;37:398–405. doi: 10.1016/0006-3002(60)90495-9. [DOI] [PubMed] [Google Scholar]
  54. Randall L. L., Hardy S. J. Synthesis of exported proteins by membrane-bound polysomes from Escherichia coli. Eur J Biochem. 1977 May 2;75(1):43–53. doi: 10.1111/j.1432-1033.1977.tb11502.x. [DOI] [PubMed] [Google Scholar]
  55. Ron E. Z. Polysome turnover during amino acid starvation in Escherichia coli. J Bacteriol. 1971 Oct;108(1):263–268. doi: 10.1128/jb.108.1.263-268.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Rosset R., Gorini L. A ribosomal ambiguity mutation. J Mol Biol. 1969 Jan 14;39(1):95–112. doi: 10.1016/0022-2836(69)90336-2. [DOI] [PubMed] [Google Scholar]
  57. SPEYER J. F., LENGYEL P., BASILIO C. Ribosomal localization of streptomycin sensitivity. Proc Natl Acad Sci U S A. 1962 Apr 15;48:684–686. doi: 10.1073/pnas.48.4.684. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. SPOTTS C. R., STANIER R. Y. Mechanism of streptomycin action on bacteria: a unitary hypothesis. Nature. 1961 Nov 18;192:633–637. doi: 10.1038/192633a0. [DOI] [PubMed] [Google Scholar]
  59. Sakai T. T., Cohen S. S. Interrelation between guanosine tetraphosphate accumulation, ribonucleic acid synthesis, and streptomycin lethality in Escherichia coli CP78. Antimicrob Agents Chemother. 1975 Jun;7(6):730–735. doi: 10.1128/aac.7.6.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Sparling P. F., Modolell J., Takeda Y., Davis B. D. Ribosomes from Escherichia coli merodiplods heterozygous for resistance to streptomycin and to spectinomycin. J Mol Biol. 1968 Nov 14;37(3):407–421. doi: 10.1016/0022-2836(68)90111-3. [DOI] [PubMed] [Google Scholar]
  61. Stern J. L., Barner H. D., Cohen S. S. The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis. J Mol Biol. 1966 May;17(1):188–217. doi: 10.1016/s0022-2836(66)80103-1. [DOI] [PubMed] [Google Scholar]
  62. Tai P. C., Wallace B. J., Davis B. D. Streptomycin causes misreading of natural messenger by interacting with ribosomes after initiation. Proc Natl Acad Sci U S A. 1978 Jan;75(1):275–279. doi: 10.1073/pnas.75.1.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Tai P. C., Wallace B. J., Herzog E. L., Davis B. D. Properties of initiation-free polysomes of Escherichia coli. Biochemistry. 1973 Feb;12(4):609–615. doi: 10.1021/bi00728a007. [DOI] [PubMed] [Google Scholar]
  64. WHITE J. R., WHITE H. L. STREPTOMYCINOID ANTIBIOTICS: SYNERGISM BY PUROMYCIN. Science. 1964 Nov 6;146(3645):772–774. doi: 10.1126/science.146.3645.772. [DOI] [PubMed] [Google Scholar]
  65. Wallace B. J., Tai P. C., Herzog E. L., Davis B. D. Partial inhibition of polysomal ribosomes of Escherichia coli by streptomycin. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1234–1237. doi: 10.1073/pnas.70.4.1234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. YAMAKI H., TANAKA N. EFFECTS OF PROTEIN SYNTHESIS INHIBITORS ON THE LETHAL ACTION OF KANAMYCIN AND STREPTOMYCIN. J Antibiot (Tokyo) 1963 Nov;16:222–226. [PubMed] [Google Scholar]

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