Skip to main content
Microbiological Reviews logoLink to Microbiological Reviews
. 1980 Sep;44(3):468–490. doi: 10.1128/mr.44.3.468-490.1980

Viruses of guinea pigs: considerations for biomedical research.

G D Hsiung, F J Bia, C K Fong
PMCID: PMC373189  PMID: 6252434

Full text

PDF
474

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen H. K., Jeppesen T. Virus-like particles in guinea pig oogonia and oocytes. J Natl Cancer Inst. 1972 Nov;49(5):1403–1410. [PubMed] [Google Scholar]
  2. Bhatt P. N., Percy D. H., Craft J. L., Jonas A. M. Isolation and characterization of a herpeslike (Hsiung-Kaplow) virus from guinea pigs. J Infect Dis. 1971 Feb;123(2):178–189. doi: 10.1093/infdis/123.2.178. [DOI] [PubMed] [Google Scholar]
  3. Bia F. J., Hastings K., Hsiung G. D. Cytomegalovirus infection in guinea pigs. III. Persistent viruria, blood transmission, and viral interference. J Infect Dis. 1979 Dec;140(6):914–920. doi: 10.1093/infdis/140.6.914. [DOI] [PubMed] [Google Scholar]
  4. Black V. H. Virus particles in primordial germ cells of fetal guinea pigs. J Natl Cancer Inst. 1974 Feb;52(2):545–551. doi: 10.1093/jnci/52.2.545. [DOI] [PubMed] [Google Scholar]
  5. Booss J., Hsiung G. D. Herpes-like virus of the guinea pig: propagation in brain tissue of guinea pigs and mice. J Infect Dis. 1971 Mar;123(3):284–291. doi: 10.1093/infdis/123.3.284. [DOI] [PubMed] [Google Scholar]
  6. Chang P. W., Hsiung G. D. Experimental infection of parainfluenza virus type 5 in mice, hamsters and monkeys. J Immunol. 1965 Oct;95(4):591–601. [PubMed] [Google Scholar]
  7. Choi Y. C., Hsiung G. D. Cytomegalovirus infection in guinea pigs. II. Transplacental and horizontal transmission. J Infect Dis. 1978 Aug;138(2):197–202. doi: 10.1093/infdis/138.2.197. [DOI] [PubMed] [Google Scholar]
  8. Choi Y. C., Swack N. S., Hsiung G. D. Effect of heparin on cytomegalovirus replication. Proc Soc Exp Biol Med. 1978 Apr;157(4):569–571. doi: 10.3181/00379727-157-40098. [DOI] [PubMed] [Google Scholar]
  9. Connor W. S., Johnson K. P. Cytomegalovirus infection in weanling guinea pigs. J Infect Dis. 1976 Nov;134(5):442–449. doi: 10.1093/infdis/134.5.442. [DOI] [PubMed] [Google Scholar]
  10. Craft J. L., Hilding D. A. Virus-like particles in the spiral ganglion of the guinea pig cochlea. Science. 1968 Dec 27;162(3861):1485–1487. doi: 10.1126/science.162.3861.1485. [DOI] [PubMed] [Google Scholar]
  11. Cuendet J., Bonifas V. Mode (nouveau) d'enveloppement d'un Herpesvirus. Pathol Microbiol (Basel) 1973;39(1):32–34. [PubMed] [Google Scholar]
  12. Dahlberg J. E., Perk K., Dalton A. J. Virus-like particles induced in guinea pig cells by 5-bromo-2'-deoxyuridine are morphologically similar to murine B-type virus. Nature. 1974 Jun 28;249(460):828–830. doi: 10.1038/249828a0. [DOI] [PubMed] [Google Scholar]
  13. Davis A. R., Nayak D. P. Expression of endogenous retroviral genes in leukemic guinea pig cells. J Virol. 1977 Aug;23(2):263–271. doi: 10.1128/jvi.23.2.263-271.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Davis A. R., Nayak D. P., Lofgren J. Induction of endogenous guinea pig retrovirus by 5-bromodeoxyuridine: amplification of virus-specific RNA. J Virol. 1978 Jun;26(3):603–614. doi: 10.1128/jvi.26.3.603-614.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Dioşi P., Georgescu L. Degeneration of cytomegalovirus-infected cells in lymph nodes of naturally infected guinea-pigs. Rev Roum Morphol Physiol. 1974;20(2):91–94. [PubMed] [Google Scholar]
  16. ENDERS A. C. A COMPARATIVE STUDY OF THE FINE STRUCTURE OF THE TROPHOBLAST IN SEVERAL HEMOCHORIAL PLACENTAS. Am J Anat. 1965 Jan;116:29–67. doi: 10.1002/aja.1001160103. [DOI] [PubMed] [Google Scholar]
  17. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  18. Feldman D. G., Gross L. Electron microscopic study of the guinea pig leukemia virus. Cancer Res. 1970 Nov;30(11):2702–2711. [PubMed] [Google Scholar]
  19. Fong C. K., Bia F., Hsiung G. D., Madore P., Chang P. W. Ultrastructural development of guinea pig cytomegalovirus in cultured guinea pig embryo cells. J Gen Virol. 1979 Jan;42(1):127–140. doi: 10.1099/0022-1317-42-1-127. [DOI] [PubMed] [Google Scholar]
  20. Fong C. K., Bia F., Hsiung G. D. Ultrastructural development and persistence of guinea pig cytomegalovirus in duet cells of guinea pig submaxillary gland. Arch Virol. 1980;64(2):97–108. doi: 10.1007/BF01318013. [DOI] [PubMed] [Google Scholar]
  21. Fong C. K., Hsiung G. D. In vitro transformation of hamster embryo cells by a guinea pig herpes-like virus. Proc Soc Exp Biol Med. 1973 Dec;144(3):974–978. doi: 10.3181/00379727-144-37723. [DOI] [PubMed] [Google Scholar]
  22. Fong C. K., Hsiung G. D. Morphogenic studies of herpesvirus and oncornavirus from leukemic and normal guinea pigs. Fed Proc. 1977 Aug;36(9):2320–2327. [PubMed] [Google Scholar]
  23. Fong C. K., Hsiung G. D. Oncornavirus of guinea pigs. 1. Morphology and distribution in normal and leukemic guinea pig cells. Virology. 1976 Apr;70(2):385–398. doi: 10.1016/0042-6822(76)90280-4. [DOI] [PubMed] [Google Scholar]
  24. Fong C. K., Hsiung G. D. The interaction between herpesvirus and oncornavirus of guineapigs: in vitro and in vivo studies. IARC Sci Publ. 1978;(24 Pt 2):981–989. [PubMed] [Google Scholar]
  25. Griffith B. P., Hsiung G. D. Cytomegalovirus infection in guinea pigs. IV. Maternal infection at different stages of gestation. J Infect Dis. 1980 Jun;141(6):787–793. doi: 10.1093/infdis/141.6.787. [DOI] [PubMed] [Google Scholar]
  26. HARTLEY J. W., ROWE W. P., HUEBNER R. J. Serial propagation of the guinea pig salivary gland virus in tissue culture. Proc Soc Exp Biol Med. 1957 Nov;96(2):281–285. doi: 10.3181/00379727-96-23455. [DOI] [PubMed] [Google Scholar]
  27. HSIUNG G. D., CHANG P. W., CUADRADO R. R., ISACSON P. STUDIES OF PARAINFLUENZA VIRUSES. 3. ANTIBODY RESPONSES OF DIFFERENT ANIMAL SPECIES AFTER IMMUNIZATION. J Immunol. 1965 Jan;94:67–73. [PubMed] [Google Scholar]
  28. Hampton E. G., Bruce M., Jackson F. L. Virus-like particles in a fibrovascular growth in guinea pigs. J Gen Virol. 1968 Jan;2(1):205–206. doi: 10.1099/0022-1317-2-1-205. [DOI] [PubMed] [Google Scholar]
  29. Hsiung G. D. Activation of guinea pig C-type virus in cultured spleen cells by 5-bromo-2'-deoxyuridine. J Natl Cancer Inst. 1972 Aug;49(2):567–570. [PubMed] [Google Scholar]
  30. Hsiung G. D., Choi Y. C., Bia F. Cytomegalovirus infection in guinea pigs. I. Viremia during acute primary and chronic persistent infection. J Infect Dis. 1978 Aug;138(2):191–196. doi: 10.1093/infdis/138.2.191. [DOI] [PubMed] [Google Scholar]
  31. Hsiung G. D., Fong C. K. Dual infection with endogenous herpes- and C-type viruses in cultured cells derived from normal and leukemic guinea pigs. Proc Soc Exp Biol Med. 1974 Dec;147(3):635–639. doi: 10.3181/00379727-147-38404. [DOI] [PubMed] [Google Scholar]
  32. Hsiung G. D., Fong C. K., Evans C. H. Prevalence of endogenous oncornavirus in guinea pigs. Intervirology. 1974;3(5-6):319–331. doi: 10.1159/000149769. [DOI] [PubMed] [Google Scholar]
  33. Hsiung G. D., Fong C. R., Lam K. M. Guinea pig leukocytes: in vivo and in vitro infection with a herpes-like virus. J Immunol. 1971 Jan;106(6):1686–1689. [PubMed] [Google Scholar]
  34. Hsiung G. D., Kaplow L. S., Booss J. Herpesvirus infection of guinea pigs. I. Isolation, characterization and pathogenicity. Am J Epidemiol. 1971 Apr;93(4):298–307. doi: 10.1093/oxfordjournals.aje.a121261. [DOI] [PubMed] [Google Scholar]
  35. Hsiung G. D., Kaplow L. S. Herpeslike virus isolated from spontaneously degenerated tissue culture derived from leukemia-susceptible guinea pigs. J Virol. 1969 Mar;3(3):355–357. doi: 10.1128/jvi.3.3.355-357.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Hsiung G. D. Latent virus infections in primate tissues with special reference to simian viruses. Bacteriol Rev. 1968 Sep;32(3):185–205. doi: 10.1128/br.32.3.185-205.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Hsiung G. D., McTighe A. H. An animal model for DNA-RNA virus interaction based upon virological and histological findings. Cancer Res. 1976 Feb;36(2 Pt 2):674–677. [PubMed] [Google Scholar]
  38. Hsiung G. D. Parainfluenza-5 virus. Infection of man and animal. Prog Med Virol. 1972;14:241–274. [PubMed] [Google Scholar]
  39. Hsiung G. D., Tenser R. B., Fong C. K. Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: growth characteristics and antigentic relationship. Infect Immun. 1976 Mar;13(3):926–933. doi: 10.1128/iai.13.3.926-933.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Hsiung G. D. Virological studies of guinea pig leukemia: an overview with reference to herpesvirus and oncornavirus. Fed Proc. 1977 Aug;36(9):2285–2289. [PubMed] [Google Scholar]
  41. Hsiung G. Natural history of herpes and C-type virus infections and their possible relation to viral oncogenesis. An animal model. Prog Med Virol. 1975;21:58–71. [PubMed] [Google Scholar]
  42. Huang A. S., Palma E. L., Hewlett N., Roizman B. Pseudotype formation between enveloped RNA and DNA viruses. Nature. 1974 Dec 20;252(5485):743–745. doi: 10.1038/252743a0. [DOI] [PubMed] [Google Scholar]
  43. Johnson K. P., Connor W. S. Guinea pig cytomegalovirus: transplacental transmission. Brief report. Arch Virol. 1979;59(3):263–267. doi: 10.1007/BF01317422. [DOI] [PubMed] [Google Scholar]
  44. Kumar M. L., Nankervis G. A. Experimental congenital infection with cytomegalovirus: a guinea pig model. J Infect Dis. 1978 Nov;138(5):650–654. doi: 10.1093/infdis/138.5.650. [DOI] [PubMed] [Google Scholar]
  45. Lam K. M., Hsiung G. D. Guinea pig herpes-like virus infections. II. Antibody response and virus persistence in mice and rabbits. Infect Immun. 1973 Mar;7(3):432–437. doi: 10.1128/iai.7.3.432-437.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Lam K. M., Hsiung G. D. Herpesvirus infection of guinea pigs. II. Transplacental transmission. Am J Epidemiol. 1971 Apr;93(4):308–313. doi: 10.1093/oxfordjournals.aje.a121262. [DOI] [PubMed] [Google Scholar]
  47. Ma B. I., Swartzendruber D. C., Murphy W. H. Detection of virus-like particles in germinal centers of normal guinea pigs. Proc Soc Exp Biol Med. 1969 Feb;130(2):586–590. doi: 10.3181/00379727-130-33613. [DOI] [PubMed] [Google Scholar]
  48. Michalides R., Schlom J., Dahlberg J., Perk K. Biochemical properties of the bromodeoxyuridine-induced guinea pig virus. J Virol. 1975 Oct;16(4):1039–1050. doi: 10.1128/jvi.16.4.1039-1050.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Michalski F. J., Fong C. K., Hsiung G. D., Schneider R. D. Induction of tumors by a guinea pig herpesvirus-transformed hamster cell line. J Natl Cancer Inst. 1976 Jun;56(6):1165–1170. doi: 10.1093/jnci/56.6.1165. [DOI] [PubMed] [Google Scholar]
  50. Middelkamp J. N., Patrizi G., Reed C. A. Light and electron microscopic studies of the guinea pig cytomegalovirus. J Ultrastruct Res. 1967 Apr;18(1):85–101. doi: 10.1016/s0022-5320(67)80233-8. [DOI] [PubMed] [Google Scholar]
  51. Murray P. R., Nayak D. P. Characterization of bromodeoxyuridine-induced endogenous guinea pig virus. J Virol. 1974 Sep;14(3):679–688. doi: 10.1128/jvi.14.3.679-688.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Nadel E., Banfield W., Burstein S., Tousimis A. J. Virus particles associated with strain 2 guinea pig leukemia (L2C/N-B). J Natl Cancer Inst. 1967 Jun;38(6):979–981. [PubMed] [Google Scholar]
  53. Nayak D. P. Endogenous guinea pig virus: equability of virus-specific DNA in normal, leukemic, and virus-producing cells. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1164–1168. doi: 10.1073/pnas.71.4.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Nayak D. P. Isolation and characterization of a herpesvirus from leukemic guinea pigs. J Virol. 1971 Oct;8(4):579–588. doi: 10.1128/jvi.8.4.579-588.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Nayak D. P., Murray P. R. Induction of type C viruses in cultured guinea pig cells. J Virol. 1973 Jul;12(1):177–187. doi: 10.1128/jvi.12.1.177-187.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Opler S. R. Observations on a new virus associated with guinea pig leukemia: preliminary note. J Natl Cancer Inst. 1967 May;38(5):797–800. [PubMed] [Google Scholar]
  57. Putman D. L., Rhim J. S. Characterization of bromodeoxyuridine-induced guinea pig type B retravirus. Fed Proc. 1977 Aug;36(9):2316–2319. [PubMed] [Google Scholar]
  58. Rhim J. S., Duh F. G., Cho H. Y., Wuu K. D., Vernon M. L. Brief communication: Activation by 5-bromo-2'-deoxyuridine of particles resembling guinea-pig leukemia virus from guinea-pig nonproducer cells. J Natl Cancer Inst. 1973 Oct;51(4):1327–1331. doi: 10.1093/jnci/51.4.1327. [DOI] [PubMed] [Google Scholar]
  59. Rhim J. S. Malignant transformation of rat embryo cells by a herpesvirus isolated from L2C guinea pig leukemia. Virology. 1977 Oct 1;82(1):100–110. doi: 10.1016/0042-6822(77)90036-8. [DOI] [PubMed] [Google Scholar]
  60. Rhim J. S., Wuu K. D., Ro H. S., Vernon M. L., Huebner R. J. Induction of guinea pig leukemia-like virus from cultured guinea pigs cells. Proc Soc Exp Biol Med. 1974 Oct;147(1):323–330. doi: 10.3181/00379727-147-38335. [DOI] [PubMed] [Google Scholar]
  61. SCHULTZ E. W., HABEL K. SA virus; a new member of the myxovirus group. J Immunol. 1959 Mar;82(3):274–278. [PubMed] [Google Scholar]
  62. Schlom J., Michalides R., Perk K., Pearson J., Dahlberg J. Biochemical properties of the B-type retravirus of guinea pigs and an agent in the plasma of guinea pigs with L2C leukemia. Fed Proc. 1977 Aug;36(9):2310–2315. [PubMed] [Google Scholar]
  63. Tenser R. B., Hsiung G. D. Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: pathogenesis and persistence in experimentally infected animals. Infect Immun. 1976 Mar;13(3):934–940. doi: 10.1128/iai.13.3.934-940.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Tenser R. B., Hsiung G. D. Oncornavirus particles in neurons of guinea pig trigeminal ganglion. J Neuropathol Exp Neurol. 1978 Sep;37(5):508–517. doi: 10.1097/00005072-197809000-00006. [DOI] [PubMed] [Google Scholar]
  65. VONEULER L., KANTOR F. S., HSIUNG G. D. STUDIES OF PARAINFLUENZA VIRUSES. I. CLINICAL, PATHOLOGICAL AND VIROLOGICAL OBSERVATIONS. Yale J Biol Med. 1963 Jun;35:523–533. [PMC free article] [PubMed] [Google Scholar]
  66. Závada J. Pseudotypes of vesicular stomatitis virus with the coat of murine leukaemia and of avian myeloblastosis viruses. J Gen Virol. 1972 Jun;15(3):183–191. doi: 10.1099/0022-1317-15-3-183. [DOI] [PubMed] [Google Scholar]

Articles from Microbiological Reviews are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES