Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1969 Nov;4(5):574–579. doi: 10.1128/jvi.4.5.574-579.1969

Simian Virus 40-Induced T and Tumor Antigens

C W Potter 1, Bridget C Mclaughlin 1, J S Oxford 1
PMCID: PMC375911  PMID: 4311792

Abstract

Antigen extracts from simian virus 40 (SV40) transplanted hamster tumors were studied by rate-zonal centrifugation. Three species or molecular forms of antigen were demonstrated. The major antigen component corresponded to a molecular weight of 65,000 to 75,000, and two larger species were detectable in smaller quantities. Similar studies were carried out on SV40 virus-induced T antigen from BSC-1 cells. Three antigen components were again detected. Quantitative differences in the expression of “T” and tumor antigen species were reproducibly found.

Full text

PDF
579

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLACK P. H., ROWE W. P., TURNER H. C., HUEBNER R. J. A SPECIFIC COMPLEMENT-FIXING ANTIGEN PRESENT IN SV40 TUMOR AND TRANSFORMED CELLS. Proc Natl Acad Sci U S A. 1963 Dec;50:1148–1156. doi: 10.1073/pnas.50.6.1148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Black P. H. The oncogenic DNA viruses: a review of in vitro transformation studies. Annu Rev Microbiol. 1968;22:391–426. doi: 10.1146/annurev.mi.22.100168.002135. [DOI] [PubMed] [Google Scholar]
  3. GILDEN R. V., CARP R. I., TAGUCHI F., DEFEND V. THE NATURE AND LOCALIZATION OF THE SV 40-INDUCED COMPLEMENT-FIXING ANTIGEN. Proc Natl Acad Sci U S A. 1965 Mar;53:684–692. doi: 10.1073/pnas.53.3.684. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gilden R. V., Beddow T. G., Huebner R. J. Production of high-titer antibody in serum and ascitic fluid of hamsters for a variety of virus-induced tumor antigens. Appl Microbiol. 1967 May;15(3):657–660. doi: 10.1128/am.15.3.657-660.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HABEL K. SPECIFIC COMPLEMENT-FIXING ANTIGENS IN POLYOMA TUMORS AND TRANSFORMED CELLS. Virology. 1965 Jan;25:55–61. doi: 10.1016/0042-6822(65)90251-5. [DOI] [PubMed] [Google Scholar]
  6. HOGGAN M. D., ROWE W. P., BLACK P. H., HUEBNER R. J. PRODUCTION OF "TUMOR-SPECIFIC" ANTIGENS BY ONCOGENIC VIRUSES DURING ACUTE CYTOLYTIC INFECTIONS. Proc Natl Acad Sci U S A. 1965 Jan;53:12–19. doi: 10.1073/pnas.53.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HOPPS H. E., BERNHEIM B. C., NISALAK A., TJIO J. H., SMADEL J. E. BIOLOGIC CHARACTERISTICS OF A CONTINUOUS KIDNEY CELL LINE DERIVED FROM THE AFRICAN GREEN MONKEY. J Immunol. 1963 Sep;91:416–424. [PubMed] [Google Scholar]
  8. HUEBNER R. J., ROWE W. P., TURNER H. C., LANE W. T. SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORS. Proc Natl Acad Sci U S A. 1963 Aug;50:379–389. doi: 10.1073/pnas.50.2.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kit S., Dubbs D. R., Frearson P. M., Melnick J. L. Enzyme induction in SV40-infected green monkey kidney cultures. Virology. 1966 May;29(1):69–83. doi: 10.1016/0042-6822(66)90197-8. [DOI] [PubMed] [Google Scholar]
  10. Kit S., Melnick J. L., Anken M., Dubbs D. R., De Torres R. A., Kitahara T. Nonidentiy of some simian virus 40-induced enzymes with tumor antigen. J Virol. 1967 Aug;1(4):684–692. doi: 10.1128/jvi.1.4.684-692.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Klein G. Tumor-specific transplantation antigens: G. H. A. Clowes memorial lecture. Cancer Res. 1968 Apr;28(4):625–635. [PubMed] [Google Scholar]
  12. MARTIN R. G., AMES B. N. A method for determining the sedimentation behavior of enzymes: application to protein mixtures. J Biol Chem. 1961 May;236:1372–1379. [PubMed] [Google Scholar]
  13. Potter C. W., Oxford J. S. Specific tumour antigen induced by chick embryo lethal orphan (CELO) virus. J Gen Virol. 1969 Mar;4(2):287–289. doi: 10.1099/0022-1317-4-2-287. [DOI] [PubMed] [Google Scholar]
  14. SABIN A. B., KOCH M. A. SOURCE OF GENETIC INFORMATION FOR SPECIFIC COMPLEMENT-FIXING ANTIGENS IN SV40 VIRUS-INDUCED TUMORS. Proc Natl Acad Sci U S A. 1964 Nov;52:1131–1138. doi: 10.1073/pnas.52.5.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  16. Stoker M. G. Effects of tumour viruses on growth regulation in cultured cells. Lancet. 1969 Feb 15;1(7590):362–365. doi: 10.1016/s0140-6736(69)91313-0. [DOI] [PubMed] [Google Scholar]
  17. Tockstein G., Polasa H., Piña M., Green M. A simple purification procedure for adenovirus type 12T and tumor antigens and some of their properties. Virology. 1968 Nov;36(3):377–386. doi: 10.1016/0042-6822(68)90162-1. [DOI] [PubMed] [Google Scholar]
  18. WASSERMAN E., LEVINE L. Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. J Immunol. 1961 Sep;87:290–295. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES