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. 1970 Mar;5(3):388–397. doi: 10.1128/jvi.5.3.388-397.1970

Cell-Free Transmission and In Vivo Replication of Marek's Disease Virus 1

K Nazerian 1, R L Witter 1
PMCID: PMC376016  PMID: 4191324

Abstract

Marek's disease virus recovered from the feather follicle of infected chickens was found to be infectious for chickens in cell-free preparations. The virus replicated in epithelial cells of the germinative layer of the feather follicle epidermis, producing both intranuclear and round or diffuse cytoplasmic inclusion bodies in the infected cells. It was found at this site 2 weeks postinoculation and prior to the development of tumor or other gross lesions. In the nucleus, many naked and a few enveloped herpesvirions were found, whereas the cytoplasm contained predominantly enveloped herpesvirions, which were usually within the cytoplasmic inclusion bodies. Approximately 80% of the extracellular virions were enveloped. Studies with both virulent and avirulent strains of the virus revealed a relationship between virulence, contagiousness, and replication of the virus in the feather follicle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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