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. 1971 Dec;8(6):821–827. doi: 10.1128/jvi.8.6.821-827.1971

Component of Strain MC29 Avian Leukosis Virus with the Property of Defectiveness

R Ishizaki 1, A J Langlois 1, J Chabot 1, J W Beard 1
PMCID: PMC376270  PMID: 4135171

Abstract

Three clones of morphologically altered cells (L−MC29) of singular properties were isolated from MC29 (subgroup A) leukosis virus-infected chick embryo cells. Supernatant fluids from cultures of the cloned cells produced no transforming or interfering activity on chick embryo cells susceptible to known avian leukosis-sarcoma viruses. No virus associated with the cells was demonstrable by fluorescent-antibody staining or by electron microscopy. All L−MC29 clone cells were activated, however, by four strains of Rous-associated viruses (RAV) representative of A, B, C, and D subgroup avian leukosis viruses and by two strains of MC29 virus. Virus L−MC29 cells activated by superinfection with RAV-1 and RAV-2 was characterized by helper-dependent and helper-independent properties. These findings suggest that the strain MC29 leukosis virus, or a component thereof, possesses properties of defectiveness similar to those of the Bryan high-titer Rous sarcoma virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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