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. 1970 Jun;19(6):955–959. doi: 10.1128/am.19.6.955-959.1970

Amphotericin B Serum Concentrations During Therapy 1

Branch T Fields Jr 1,2, Joseph H Bates 1, Robert S Abernathy 1
PMCID: PMC376832  PMID: 5456013

Abstract

Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations of this drug that are produced in these patients. Because current data are conflicting, the magnitude of these concentrations was restudied by using a bioassay which gave precise and accurate results. The highest of 155 serum concentrations was 2.01 μg/ml. Mean concentrations were 1.21, 0.62, and 0.32 μg/ml, at 1, 18, and 42 hr, respectively, after intravenous infusion of amphotericin B. This drug was detected in serum 7 weeks after completion of treatment, but it could not be detected 13 weeks after treatment. Drug levels did not appreciably decrease in serum stored for 8 to 9 months at − 10 C. Unequal serum content in assay tubes and measurement of assay turbidity by visual inspection may explain previously reported amphotericin B levels of 3.0 to 12.5 μg/ml.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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