Abstract
Seventy-eight of 420 clinical isolates of Pseudomonas aeruginosa yielded zones of inhibition of less than 12 mm in diameter around 10-μg discs of gentamicin sulfate when tested by the standardized Bauer-Kirby disc diffusion method. Of 153 strains chosen from these isolates, one strain (0.65%) required 25 μg of gentamicin per ml for inhibition; the remainder (99.35%) were inhibited by 6 μg/ml or less of the antibiotic. It is recommended that those isolates of P. aeruginosa that yield zones of inhibition less than 12 mm in diameter be disc susceptibility-tested once more; those isolates that give zones of inhibition of less than 12 mm upon repeated examination should then be subjected to the broth dilution test before they are designated as sensitive or resistant to gentamicin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BULGER R. J., SIDELL S., KIRBY W. M. LABORATORY AND CLINICAL STUDIES OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC. Ann Intern Med. 1963 Nov;59:593–604. doi: 10.7326/0003-4819-59-5-593. [DOI] [PubMed] [Google Scholar]
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Garrod L. P., Waterworth P. M. Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin. J Clin Pathol. 1969 Sep;22(5):534–538. doi: 10.1136/jcp.22.5.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kirby W. M., Standiford H. C. Gentamicin: in vitro studies. J Infect Dis. 1969 Apr-May;119(4):361–363. doi: 10.1093/infdis/119.4-5.361. [DOI] [PubMed] [Google Scholar]
- RUBENIS M., KOZIJ V. M., JACKSON G. G. LABORATORY STUDIES ON GENTAMICIN. Antimicrob Agents Chemother (Bethesda) 1963;161:153–156. [PubMed] [Google Scholar]
- Sander J., Blasius C. Untersuchungen ber die Wirksamkeit von Gentamycin gegen bestimmte grammnegative Stäbchenbakterien. Dtsch Med Wochenschr. 1968 Jul 19;93(29):1401–1404. doi: 10.1055/s-0028-1110752. [DOI] [PubMed] [Google Scholar]
- Waitz J. A., Weinstein M. J. Recent microbiological studies with gentamicin. J Infect Dis. 1969 Apr-May;119(4):355–360. doi: 10.1093/infdis/119.4-5.355. [DOI] [PubMed] [Google Scholar]
- Washington J. A., 2nd, Ritts R. E., Jr, Martin W. J. In vitro susceptibility of gram-negative bacilli to gentamicin. Mayo Clin Proc. 1970 Feb;45(2):146–149. [PubMed] [Google Scholar]