Skip to main content
Applied Microbiology logoLink to Applied Microbiology
. 1969 Oct;18(4):622–627. doi: 10.1128/am.18.4.622-627.1969

Biosynthesis of Ochratoxin A1

J W Searcy a, N D Davis a, U L Diener a
PMCID: PMC378048  PMID: 5369298

Abstract

Biosynthesis of ochratoxin A by Aspergillus ochraceus Wilh. was investigated by radiolabeling experiments in which phenylalanine-1-14C and sodium acetate-2-14C were supplied to the fungus in sucrose-yeast extract medium. Results showed that phenylalanine was incorporated unaltered into the phenylalanine moiety of ochratoxin A, whereas the isocoumarin moiety of ochratoxin A was mostly derived via acetate condensation.

Full text

PDF
625

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Biollaz M., Büchi G., Milne G. Biosynthesis of aflatoxins. J Am Chem Soc. 1968 Aug 28;90(18):5017–5019. doi: 10.1021/ja01020a042. [DOI] [PubMed] [Google Scholar]
  2. Christensen C. M., Fanse H. A., Nelson G. H., Bates F., Mirocha C. J. Microflora of black and red pepper. Appl Microbiol. 1967 May;15(3):622–626. doi: 10.1128/am.15.3.622-626.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Christensen C. M., Nelson G. H., Mirocha C. J., Bates F. Toxicity to experimental animals of 943 isolates of fungi. Cancer Res. 1968 Nov;28(11):2293–2295. [PubMed] [Google Scholar]
  4. Davis N. D., Searcy J. W., Diener U. L. Production of ochratoxin A by Aspergillus ochraceus in a semisynthetic medium. Appl Microbiol. 1969 May;17(5):742–744. doi: 10.1128/am.17.5.742-744.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ferreira N. P. The effect of amino acids on the production of ochratoxin A in chemically defined media. Antonie Van Leeuwenhoek. 1968;34(4):433–440. doi: 10.1007/BF02046465. [DOI] [PubMed] [Google Scholar]
  6. IBRAHIM R. K., TOWERS G. H. Studies of hydrangenol in Hydrangea macrophylla Ser. II. Biosynthesis of hydrangenol from C14-labelled compounds. Can J Biochem Physiol. 1962 Apr;40:449–453. [PubMed] [Google Scholar]
  7. IBRAHIM R. K., TOWERS G. H. Studies of hydrangenol in hydrangea macrophylla Ser. I. Isolation, identification, and biosynthesis from C 14-labelled compounds. Can J Biochem Physiol. 1960 Jul;38:627–634. [PubMed] [Google Scholar]
  8. Nitta K., Yamamoto Y., Inoue T., Hyodo T. Studies on the metabolic products of Oospora astringenes. VII. Biogenesis of oospolactone and oosponol. Chem Pharm Bull (Tokyo) 1966 Apr;14(4):363–369. doi: 10.1248/cpb.14.363. [DOI] [PubMed] [Google Scholar]
  9. Scott D. B. Toxigenic fungi isolated from cereal and legume products. Mycopathol Mycol Appl. 1965 Apr 14;25(3):213–222. doi: 10.1007/BF02049914. [DOI] [PubMed] [Google Scholar]
  10. Steyn P. S., Holzapfel C. W. The synthesis of ochratoxins A and B metabolites of Aspergillus ochraceus Wilh. Tetrahedron. 1967 Nov;23(11):4449–4461. doi: 10.1016/s0040-4020(01)88843-8. [DOI] [PubMed] [Google Scholar]
  11. Theron J. J., van der Merwe K. J., Liebenberg N., Joubert H. J., Nel W. Acute liver injury in ducklings and rats as a result of ochratoxin poisoning. J Pathol Bacteriol. 1966 Apr;91(2):521–529. doi: 10.1002/path.1700910228. [DOI] [PubMed] [Google Scholar]
  12. Van Walbeek W., Scott P. M., Thatcher F. S. Mycotoxins from food-borne fungi. Can J Microbiol. 1968 Feb;14(2):131–137. doi: 10.1139/m68-022. [DOI] [PubMed] [Google Scholar]
  13. WORONICK C. L., JOHNSON M. J. Carbon dioxide fixation by cell-free extracts of Aspergillus niger. J Biol Chem. 1960 Jan;235:9–15. [PubMed] [Google Scholar]
  14. van der Merwe K. J., Steyn P. S., Fourie L., Scott D. B., Theron J. J. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 1965 Mar 13;205(976):1112–1113. doi: 10.1038/2051112a0. [DOI] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES