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. 1996 Oct 29;93(22):12142–12149. doi: 10.1073/pnas.93.22.12142

The N-end rule: functions, mysteries, uses.

A Varshavsky 1
PMCID: PMC37957  PMID: 8901547

Abstract

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications.

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Selected References

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