Skip to main content
PMC home page
Applied Microbiology logoLink to Applied Microbiology
. 1974 Apr;27(4):777–783. doi: 10.1128/am.27.4.777-783.1974

Production of a Potent Vaccine from the Attenuated M-44 Strain of Coxiella burneti

David M Robinson 1, Sherman E Hasty 1
PMCID: PMC380134  PMID: 4825980

Abstract

The attenuated M-44 strain of Coxiella burneti was heated to free it of adventitious agents that may have been present. Parallel titrations of the strain before and after heating indicated that the virulence for guinea pigs was markedly decreased. Guinea pigs immunized with the strain derived after heat treatment were protected from the effects of challenge with C. burneti in either phase I or II.

Full text

PDF
780

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERMAN S., COLE G., LOWENTHAL J. P., GOCHENOUR R. B. Safety test for Q fever vaccine. J Bacteriol. 1960 May;79:747–751. doi: 10.1128/jb.79.5.747-751.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berman S., Gochenour R. B., Cole G., Lowenthal J. P., Benenson A. S. METHOD FOR THE PRODUCTION OF A PURIFIED DRY Q FEVER VACCINE. J Bacteriol. 1961 May;81(5):794–799. doi: 10.1128/jb.81.5.794-799.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. GENIG V. A. [Atenuated variant "M" of Rickettsia burneti as a possible live vaccine against Q-fever]. Vestn Akad Med Nauk SSSR. 1960;15(2):46–57. [PubMed] [Google Scholar]
  4. GIMENEZ D. F. STAINING RICKETTSIAE IN YOLK-SAC CULTURES. Stain Technol. 1964 May;39:135–140. doi: 10.3109/10520296409061219. [DOI] [PubMed] [Google Scholar]
  5. Genig V. A., Kniazeva E. N., Tsel'nikov P. S., Miroshnichenko M. M. Opyt massovoi immunizatsii liudei zhivoi vaktsinoi M-44 protiv Ku likhoradki. I. Podkozhnyi metod immunizatsii. Vopr Virusol. 1965 May-Jun;10(3):319–323. [PubMed] [Google Scholar]
  6. JACKSON E. B., SMADEL J. E. Immunization against scrub typhus. II. Preparation of lyophilized living vaccine. Am J Hyg. 1951 May;53(3):326–331. doi: 10.1093/oxfordjournals.aje.a119457. [DOI] [PubMed] [Google Scholar]
  7. Kenyon R. H., Acree W. M., Wright G. G., Melchior F. W., Jr Preparation of vaccines for Rocky Mountain spotted fever from rickettsiae propagated in cell culture. J Infect Dis. 1972 Feb;125(2):146–152. doi: 10.1093/infdis/125.2.146. [DOI] [PubMed] [Google Scholar]
  8. ORMSBEE R. A. A method of purifying Coxiella burnetii and other pathogenic Rickettsiae. J Immunol. 1962 Jan;88:100–108. [PubMed] [Google Scholar]
  9. ORMSBEE R. A., BELL E. J., LACKMAN D. B., TALLENT G. THE INFLUENCE OF PHASE ON THE PROTECTIVE POTENCY OF Q FEVER VACCINE. J Immunol. 1964 Mar;92:404–412. [PubMed] [Google Scholar]
  10. Spicer D. S., DeSanctis A. N., Beiler J. M. Preparation of highly purified concentrates of Coxiella burneti. Proc Soc Exp Biol Med. 1970 Dec;135(3):706–708. doi: 10.3181/00379727-135-35125. [DOI] [PubMed] [Google Scholar]
  11. Sterkhova A. N. Immunizatsiia liudei zhivoi vaktsinoi M-44 protiv likhoradki Ku. Zh Mikrobiol Epidemiol Immunobiol. 1965 Dec;42(12):48–52. [PubMed] [Google Scholar]
  12. VIVONA S., LOWENTHAL J. P., BERMAN S., BENENSON A. S., SMADEL J. E. REPORT OF A FIELD STUDY WITH Q FEVER VACCINE. Am J Hyg. 1964 Mar;79:143–153. doi: 10.1093/oxfordjournals.aje.a120370. [DOI] [PubMed] [Google Scholar]
  13. ZDRODOVSKII P. F., GENIG V. A. [The problem of a live vaccine against Q fever]. Vopr Virusol. 1962 May-Jun;7:355–358. [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES