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. 1972 Nov;24(5):841–843. doi: 10.1128/am.24.5.841-843.1972

Isolation of a New Soluble Antigen from the Yeast Phase of Histoplasma capsulatum

Michael W Reeves 1, Leo Pine 1, Leo Kaufman 1, David McLaughlin 1
PMCID: PMC380675  PMID: 4640739

Abstract

A method is described by which a soluble antigen was prepared from the yeast phase of Histoplasma capsulatum. This soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. In complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, whereas conventional whole-cell yeast antigens reacted in 47.3% of 91 tests with heterologous sera. The reactivities of the two types of antigens with homologous sera were essentially the same.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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