Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1979 Apr;76(4):2047–2051. doi: 10.1073/pnas.76.4.2047

Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis.

W W Hall, R A Lamb, P W Choppin
PMCID: PMC383531  PMID: 287042

Abstract

Studies on the immunoprecipitation of the proteins of several different measles and subacute sclerosing panencephalitis (SSPE) virus strains from lysates of infected cells have revealed a relative lack of antibodies to the nonglycosylated viral membrane protein (M) in the sera of patients with SSPE, in contrast to a high level of antibodies to other viral proteins. No evidence was found for the existence of a large number of antigenically unique M proteins. In contrast to SSPE sera, other hyperimmune human or rabbit sera precipitated M protein as well as the other viral proteins. The results suggest that in patients with SSPE there is either diminished synthesis of M, or it is not recognized normally by the immune system, and that an abnormality in M protein is involved in the pathogenesis of SSPE. Although differences in electrophoretic mobility of the M proteins and several other viral proteins were observed among different SSPE and measles strains, there was no pattern characteristic of SSPE strains, nor could these strains be distinguished by peptide mapping.

Full text

PDF
2051

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Graves M. C., Silver S. M., Choppin P. W. Measles virus polypeptides synthesis in infected cells. Virology. 1978 May 1;86(1):254–263. doi: 10.1016/0042-6822(78)90025-9. [DOI] [PubMed] [Google Scholar]
  2. Hall W. W., Kiessling W., ter Meulen V. Membrane proteins of subacute sclerosing panencephalitis and measles viruses. Nature. 1978 Mar 30;272(5652):460–462. doi: 10.1038/272460a0. [DOI] [PubMed] [Google Scholar]
  3. Kronvall G., Frommel D. Definition of staphylococcal protein A reactivity for human immunoglobulin G fragments. Immunochemistry. 1970 Jan;7(1):124–127. doi: 10.1016/0019-2791(70)90036-4. [DOI] [PubMed] [Google Scholar]
  4. Lamb R. A., Choppin P. W. The synthesis of Sendai virus polypeptides in infected cells. III. Phosphorylation of polypeptides. Virology. 1977 Sep;81(2):382–397. doi: 10.1016/0042-6822(77)90154-4. [DOI] [PubMed] [Google Scholar]
  5. Lamb R. A., Etkind P. R., Choppin P. W. Evidence for a ninth influenza viral polypeptide. Virology. 1978 Nov;91(1):60–78. doi: 10.1016/0042-6822(78)90355-0. [DOI] [PubMed] [Google Scholar]
  6. McSharry J. J., Compans R. W., Choppin P. W. Proteins of vesicular stomatitis virus and of phenotypically mixed vesicular stomatitis virus-simian virus 5 virions. J Virol. 1971 Nov;8(5):722–729. doi: 10.1128/jvi.8.5.722-729.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mehta P. D., Kane A., Thormar H. Quantitation of measles virus-specific immunoglobulins in serum, CSF, and brain extract from patients with subactue sclerosing panencephalitis. J Immunol. 1977 Jun;118(6):2254–2261. [PubMed] [Google Scholar]
  8. Peluso R. W., Lamb R. A., Choppin P. W. Polypeptide synthesis in simian virus 5-infected cells. J Virol. 1977 Jul;23(1):177–187. doi: 10.1128/jvi.23.1.177-187.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tyrrell D. L., Norrby E. Structural polypeptides of measles virus. J Gen Virol. 1978 May;39(2):219–229. doi: 10.1099/0022-1317-39-2-219. [DOI] [PubMed] [Google Scholar]
  10. Vandvik B., Norrby E. Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1060–1063. doi: 10.1073/pnas.70.4.1060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wechsler S. L., Fields B. N. Differences between the intracellular polypeptides of measles and subacute sclerosing panencephalitis virus. Nature. 1978 Mar 30;272(5652):458–460. doi: 10.1038/272458a0. [DOI] [PubMed] [Google Scholar]
  12. Wechsler S. L., Fields B. N. Intracellular synthesis of measles virus-specified polypeptides. J Virol. 1978 Jan;25(1):285–297. doi: 10.1128/jvi.25.1.285-297.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. ter Meulen V., Katz M., Müller D. Subacute sclerosing panencephalitis: a review. Curr Top Microbiol Immunol. 1972;57:1–38. doi: 10.1007/978-3-642-65297-4_1. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES