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. 1979 May;76(5):2350–2353. doi: 10.1073/pnas.76.5.2350

Sodium-induced calcium release from mitochondria in brown adipose tissue.

M H Al-Shaikhaly, J Nedergaard, B Cannon
PMCID: PMC383598  PMID: 287079

Abstract

Coupled mitochondria of brown adipose tissue can accumulate Ca2+ if a substrate is present. The Ca2+ is released by addition of 20 mM Na+, but not by addition of K+ or choline +. Energy-dissipating Na+-induced Ca2+ cycling occurs maximally with 20 mM Na+ and 10 microM Ca2+. In brown adipocytes, the Ca2+ ionophore A23187 and the Na+ ionophore monensin increase respiration if substrate is added, and incubation in a low-Na+ buffer decreases norepinephrine-induced respiration. Thus Na+-induced Ca2+ release takes place in brown adipose tissue; released Ca2+ could have a regulatory or thermogenic role or both.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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