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. 1983 Jul;80(14):4474–4478. doi: 10.1073/pnas.80.14.4474

Idiotypic manipulation in mice: BALB/c mice can express the crossreactive idiotype of A/J mice.

M Moser, O Leo, J Hiernaux, J Urbain
PMCID: PMC384061  PMID: 6576348

Abstract

The response of A/J mice to arsonate-coupled keyhole limpet hemocyanin is characterized by a crossreactive idiotype (CRIA). CRIA+ antibodies are restricted to the Igh-Ic haplotype and are never expressed in BALB/c mice after immunization with antigen. Studies at the DNA level suggest that the gene encoding the CRIA heavy chain in A/J mice is probably absent in the genome of BALB/c mice. Despite this, using the immunization cascade tool, we have been able to induce the expression of CRIA+ antibodies in BALB/c mice. These studies led to an apparent paradox, whose understanding will provide new insights into the regulatory mechanisms of the immune system. We suggest that clones secreting CRIA-like Igs in BALB/c mice are "somatic variants" that could arise from gene conversion events.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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