Abstract
Serotonin and 5-hydroxykynurenamine caused dose-related contractions in the spiral strips of dog basilar arteries. The potency of 5-hydroxykynurenamine was approximately 1/100 that of serotonin, the former frequently causing a transient relaxation preceding the contraction. The contractile responses to 5-hydroxykynurenamine and serotonin were attenuated by methysergide. Treatment with 5-hydroxykynurenamine inhibited the response to serotonin, and this inhibitory effect was not completely reversed by removal of 5-hydroxykynurenamine from the bathing medium. The contractile response to K+ was only slightly attenuated by high concentrations of 5-hydroxykynurenamine. It appears that 5-hydroxykynurenamine and serotonin share receptors in dog basilar arteries and that the effect of serotonin is specifically antagonized by 5-hydroxykynurenamine.
Keywords: serotonin, amine, antagonist, artery
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOHR D. F., GOULET P. L., TAQUINI A. C., Jr Direct tension recording from smooth muscle of resistance vessels from various organs. Angiology. 1961 Oct;12:478–485. doi: 10.1177/000331976101201009. [DOI] [PubMed] [Google Scholar]
- Hirata F., Hayaishi O. New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase. Biochem Biophys Res Commun. 1972 Jun 9;47(5):1112–1119. doi: 10.1016/0006-291x(72)90949-7. [DOI] [PubMed] [Google Scholar]
- Nielsen K. C., Owman C. Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat. Brain Res. 1971 Mar 19;27(1):33–42. doi: 10.1016/0006-8993(71)90370-2. [DOI] [PubMed] [Google Scholar]
- Toda N., Fujita Y. Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine, and transmural electrical stimulation. Circ Res. 1973 Jul;33(1):98–104. doi: 10.1161/01.res.33.1.98. [DOI] [PubMed] [Google Scholar]
- Toda N., Usui H., Nishino N., Fujiwara M. Cardiovascular effects of capsaicin in dogs and rabbits. J Pharmacol Exp Ther. 1972 Jun;181(3):512–521. [PubMed] [Google Scholar]