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. 1974 Apr;71(4):1418–1421. doi: 10.1073/pnas.71.4.1418

The Three-State Model: A Minimal Allosteric Description of Homotropic and Heterotropic Effects in the Binding of Ligands to Hemoglobin

Allen P Minton *, Kiyohiro Imai †,‡
PMCID: PMC388240  PMID: 4364537

Abstract

The effect of hydrogen ion, chloride, and 2,3-diphosphoglycerate upon the oxygen binding of hemoglobin may be satisfactorily described by an allosteric model employing three affinity states. The allosteric two-state model does not provide even an approximate description except under defined extreme conditions. In particular, the two-state model cannot provide a correct interpretation of recently reported electron spin resonance and nuclear magnetic resonance data.

Keywords: oxygen binding, affinity states, effector substances

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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