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. 1974 Jul;71(7):2646–2650. doi: 10.1073/pnas.71.7.2646

Oxaziridines as Possible Intermediates in Flavin Monooxygenases

H W Orf *, D Dolphin †,‡
PMCID: PMC388523  PMID: 4368986

Abstract

The enzymatic hydroxylation reactions of flavin monooxygenases are suggested to involve an oxaziridine as the active oxygenating agent. The chemistry of these monooxygenases and their nonenzymatic model systems are consistent with an oxaziridine intermediate. Several advantages of the oxaziridine model over the previously proposed “carbonyl oxide” and flavin peroxide models are discussed.

Keywords: oxaziranes, pteridines, molecular orbital calculations

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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