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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1975 Nov;72(11):4541–4545. doi: 10.1073/pnas.72.11.4541

Effect of temporal fluctuation of selection coefficient on gene frequency in a population.

N Takahata, K Ishii, H Matsuda
PMCID: PMC388758  PMID: 1060137

Abstract

The diffusion equations describing the change of gene frequencies are extended to indlude the effect of temporal fluctuation of selection coefficient that may persist for some generations. The equilibrium distribution of gene frequencies and the fixation probability of a mutant gene are obtained from the extended equations. Comparison is made with the experimental data on protein polymorphism. A possible bearing of the fluctuation of selection coefficient on the problem of molecular evolution is discussed in relation to the neutral theory.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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