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. 1971 Feb;68(2):505–508. doi: 10.1073/pnas.68.2.505

Asynchronous Synthesis of the Complementary Strands of the Reovirus Genome

Michael Schonberg *, Samuel C Silverstein *, Daniel H Levin *, George Acs *
PMCID: PMC388970  PMID: 5277109

Abstract

The mechanism of replication of the double-stranded RNA genome of reovirus has been analyzed by tracing the fate of the parental double-stranded RNA genome and by determining whether the complementary strands, which comprise the progeny double-stranded RNA, are synthesized simultaneously or sequentially. The results indicate that the parental double-stranded RNA is conserved as the original duplex molecule within a subviral particle throughout the viral replicative cycle. The complementary strands, which form the progeny double-stranded RNA, are produced asynchronously. Minus strands are synthesized on preformed plus-strand templates, whereas plus strands appear to be synthesized on double-stranded RNA templates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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