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. 1971 Mar;68(3):619–624. doi: 10.1073/pnas.68.3.619

Mammalian Peptide Chain Termination, II. Codon Specificity and GTPase Activity of Release Factor

Arthur L Beaudet 1, C T Caskey 1
PMCID: PMC389002  PMID: 5276771

Abstract

In vitro peptide chain termination with release factor preparations from rabbit reticulocytes, guinea pig liver, or Chinese hamster liver is directed with UAAA, UAGA, or UGAA, suggesting that UAA, UAG, and UGA are terminator condons for mammalian cells. Purified release factor from rabbit reticulocytes has ribosomaldependent GTPase activity, which is stimulated by UAAA. GTP hydrolysis appears requisite for in vitro peptide chain termination in mammals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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