Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1971 Apr;68(4):836–840. doi: 10.1073/pnas.68.4.836

Viruses as an Aid to Cancer Therapy: Regression of Solid and Ascites Tumors in Rodents After Treatment with Bovine Enterovirus

M W Taylor 1, B Cordell 1, M Souhrada 1, S Prather 1
PMCID: PMC389055  PMID: 4323792

Abstract

Treatment of ascites and solid tumors in mice (Sarcoma-1 and Ehrlich ascites carcinoma) with bovine enterovirus-1 resulted in regression of the tumors without any pathological effect on the animals. Death of mice with lymphatic-leukemia L4946 was delayed after such treatment. The oncolytic specificity of the virus does not appear to involve the production of interferon, but requires specific adsorption of virus to the tumor cells. The specificity of killing extends to cells in culture, since viral-transformed cells and oncogenic cells are susceptible to the virus, in contrast to cells of untransformed lines and cells of primary cultures, which are resistant.

The possibility of utilizing the specificity of nonvirulent viruses in therapeutic treatment of human cancers is considered.

Full text

PDF
837

Images in this article

838Image
on p.838
838Image
on p.838
838Image
on p.838
838Image
on p.838

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barya M. A., Moll T., Mattson D. E. Antigenic analysis of bovine enteroviruses through studies of the kinetics of neutralization. Am J Vet Res. 1967 Sep;28(126):1283–1294. [PubMed] [Google Scholar]
  2. Burger M. M. A difference in the architecture of the surface membrane of normal and virally transformed cells. Proc Natl Acad Sci U S A. 1969 Mar;62(3):994–1001. doi: 10.1073/pnas.62.3.994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. MOORE A. E. Effects of viruses on tumors. Annu Rev Microbiol. 1954;8:393–410. doi: 10.1146/annurev.mi.08.100154.002141. [DOI] [PubMed] [Google Scholar]
  4. McLAREN L. C., HOLLAND J. J., SYVERTON J. T. The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origin. J Exp Med. 1959 May 1;109(5):475–485. doi: 10.1084/jem.109.5.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Molomut N., Padnos M. Inhibition of transplantable and spontaneous murine tumours by the M-P virus. Nature. 1965 Dec 4;208(5014):948–950. doi: 10.1038/208948a0. [DOI] [PubMed] [Google Scholar]
  6. SOUTHAM C. M. Present status of oncolytic virus studies. Trans N Y Acad Sci. 1960 Jun;22:657–673. doi: 10.1111/j.2164-0947.1960.tb00739.x. [DOI] [PubMed] [Google Scholar]
  7. Taylor M. W., Davidson J. N., Land C., Wall R. Virus-induced regression of tumor growth. J Natl Cancer Inst. 1970 Mar;44(3):515–519. [PubMed] [Google Scholar]
  8. WHEELOCK E. F., DINGLE J. H. OBSERVATIONS ON THE REPEATED ADMINISTRATION OF VIRUSES TO A PATIENT WITH ACUTE LEUKEMIA. A PRELIMINARY REPORT. N Engl J Med. 1964 Sep 24;271:645–651. doi: 10.1056/NEJM196409242711302. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES