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. 1971 Aug;68(8):1791–1795. doi: 10.1073/pnas.68.8.1791

Translocation of Messenger RNA and “Accommodation” of fMet-tRNA

Sigrid S Thach 1, Robert E Thach 1
PMCID: PMC389294  PMID: 5288766

Abstract

Messenger RNA is moved a distance of approximately three nucleotides in the 5′ direction relative to the ribosome during the translocation of peptidyl-tRNA from the A to the P site. This movement is catalyzed by G factor and is dependent on the hydrolysis of GTP. In contrast, mRNA is not moved during the f2-catalyzed hydrolysis of GTP that is involved in the activation of ribosome-bound fMet-tRNA. This second type of GTP-dependent reaction has been named “Accommodation”.

Keywords: GMP-PCP, elongation factors, initiation factors, oligonucleotides, ribosomes

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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