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. 1971 Oct;68(10):2357–2360. doi: 10.1073/pnas.68.10.2357

A Model for Protein Synthesis Involving the Intermediate Formation of Peptidyl-5S RNA

Ilse Dorothea Raacke 1
PMCID: PMC389421  PMID: 5289870

Abstract

A model for protein synthesis is proposed in which the donor for the peptide elongation reaction is peptidyl-5S RNA. Space-filling models show that peptide bond formation between peptidyl-5S RNA and aminoacyl-tRNA is eminently feasible from a stereochemical point of view. The peptide is transferred to 5S RNA, while at the same time the deacylated tRNA is exchanged by a new aminoacyl-tRNA acceptor. Two peptidyl transferases are required by the model, both of which have sites for binding the termini of both aminoacyl-tRNA and peptidyl-5S RNA. The model makes detailed predictions about the properties of the transferases.

Keywords: peptidyl transferases

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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