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. 1971 Oct;68(10):2448–2452. doi: 10.1073/pnas.68.10.2448

Selective Associations of Hormonal Steroids with Aminoacyl Transfer RNAs and Control of Protein Synthesis*

Ruei-Chen Chin 1, Chev Kidson 1,†
PMCID: PMC389441  PMID: 4944626

Abstract

The hormonal steroids progesterone, estradiol, testosterone, and 5α-dihydrotestosterone bind to aminoacyl-tRNA, but not to deacylated tRNA, implying that a change in conformation of tRNA occurs on aminoacylation. Binding is restricted to a few tRNA species and depends on the structure of both tRNA and steroid. There is one binding site per aminoacyl-tRNA molecule, the specificity of which appears to depend on a restricted, single-stranded loop sequence and on the tRNA conformation. By binding to an aminoacyl-tRNA, a steroid can control polypeptide synthesis in a model in vitro system by inhibiting chain elongation under conditions where aminoacyl-tRNA concentration is rate-limiting.

Keywords: testosterone, progesterone, estradiol, yeast tRNA, E. coli tRNA

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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