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. 1971 Oct;68(10):2484–2487. doi: 10.1073/pnas.68.10.2484

Mutant Strains of Escherichia coli K12 That Use D-Amino Acids

Jonathan Kuhn 1, Ronald L Somerville 1
PMCID: PMC389449  PMID: 4400212

Abstract

A series of mutations has been isolated that confer upon amino-acid auxotrophs of Escherichia coli K-12 the ability to grow when fed various D-amino acids. Several distinct systems, mediating cellular use of the D-isomers of leucine, histidine, phenylalanine, tyrosine, tryptophan, isoleucine, and valine, can be mutationally activated. Mutations leading to D-tryptophan use (dadR) all map near purB. They result in high activities of an enzyme that deaminates D-amino acids. Neither the enzymes of the tryptophan biosynthetic pathway nor tryptophanase (EC 4.2.1.e) are involved in D-tryptophan utilization.

Keywords: histidine, phenyalanine, tryptophan, keto acid, deamination, membrane transport

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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