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. 1985 Aug;82(15):5117–5120. doi: 10.1073/pnas.82.15.5117

Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.

W van Eden, J Holoshitz, Z Nevo, A Frenkel, A Klajman, I R Cohen
PMCID: PMC390510  PMID: 3927297

Abstract

Adjuvant arthritis characterized by chronic inflammation of the joints of rats is induced by immunization to Mycobacterium tuberculosis. To learn how autoimmune arthritis may be caused by a microbial antigen, we isolated a T-lymphocyte clone specific for M. tuberculosis antigens that was strongly arthritogenic. We now report that the clone recognized, in addition to M. tuberculosis antigens, antigens present in human synovial fluid, medium of chondrocyte cultures, and proteoglycans purified from cartilage. These observations indicate that the target antigen for the arthritogenic clone resides in the proteoglycan component of cartilage. As this arthritogenic clone shows specificity for both a M. tuberculosis antigen and a cartilage constituent we conclude that disease is probably caused by antigenic cross-reactivity. Thus, an autoimmune disease may be triggered by structural mimicry between antigens in the environment and self-antigens in the individual.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ben-Nun A., Cohen I. R. Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J Immunol. 1982 Jul;129(1):303–308. [PubMed] [Google Scholar]
  2. Ben-Nun A., Wekerle H., Cohen I. R. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature. 1981 Jul 2;292(5818):60–61. doi: 10.1038/292060a0. [DOI] [PubMed] [Google Scholar]
  3. Chaparas S. D., Thor D. E., Godfrey H. P., Baer H., Hedrick S. R. Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation. Science. 1970 Nov 6;170(3958):637–639. doi: 10.1126/science.170.3958.637. [DOI] [PubMed] [Google Scholar]
  4. Geczy A. F., Yap J. HLA-B27, Klebsiella, and ankylosing spondylitis. Lancet. 1979 Mar 31;1(8118):719–720. doi: 10.1016/s0140-6736(79)91166-8. [DOI] [PubMed] [Google Scholar]
  5. Hascall V. C., Kimura J. H. Proteoglycans: isolation and characterization. Methods Enzymol. 1982;82(Pt A):769–800. doi: 10.1016/0076-6879(82)82102-2. [DOI] [PubMed] [Google Scholar]
  6. Holoshitz J., Matitiau A., Cohen I. R. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. J Clin Invest. 1984 Jan;73(1):211–215. doi: 10.1172/JCI111193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Holoshitz J., Naparstek Y., Ben-Nun A., Cohen I. R. Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science. 1983 Jan 7;219(4580):56–58. doi: 10.1126/science.6336851. [DOI] [PubMed] [Google Scholar]
  8. Holoshitz J., Naparstek Y., Ben-Nun A., Marquardt P., Cohen I. R. T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis. Eur J Immunol. 1984 Aug;14(8):729–734. doi: 10.1002/eji.1830140811. [DOI] [PubMed] [Google Scholar]
  9. Kaplan M. H. Autoantibodies to heart and rheumatic fever: the induction of autoimmunity to heart by streptococcal antigen cross-reactive with heart. Ann N Y Acad Sci. 1965 Jun 30;124(2):904–915. doi: 10.1111/j.1749-6632.1965.tb19014.x. [DOI] [PubMed] [Google Scholar]
  10. Maron R., Zerubavel R., Friedman A., Cohen I. R. T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J Immunol. 1983 Nov;131(5):2316–2322. [PubMed] [Google Scholar]
  11. Nevo Z., Horwitz A. L., Dorfmann A. Synthesis of chondromucoprotein by chondrocytes in suspension culture. Dev Biol. 1972 May;28(1):219–228. doi: 10.1016/0012-1606(72)90139-x. [DOI] [PubMed] [Google Scholar]
  12. Nevo Z., Michaeli D., Daentl D. L. Examination of core protein of proteoglycans. I. abnormal PG in auriculoepiphyseal dysplasia. Exp Mol Pathol. 1978 Apr;28(2):247–255. doi: 10.1016/0014-4800(78)90055-2. [DOI] [PubMed] [Google Scholar]
  13. PEARSON C. M. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956 Jan;91(1):95–101. doi: 10.3181/00379727-91-22179. [DOI] [PubMed] [Google Scholar]
  14. Shoenfeld Y., Rauch J., Massicotte H., Datta S. K., André-Schwartz J., Stollar B. D., Schwartz R. S. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N Engl J Med. 1983 Feb 24;308(8):414–420. doi: 10.1056/NEJM198302243080802. [DOI] [PubMed] [Google Scholar]
  15. Trentham D. E., Townes A. S., Kang A. H. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977 Sep 1;146(3):857–868. doi: 10.1084/jem.146.3.857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Whitehouse D. J., Whitehouse M. W., Pearson C. M. Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature. 1969 Dec 27;224(5226):1322–1322. doi: 10.1038/2241322a0. [DOI] [PubMed] [Google Scholar]

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