Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1985 Aug;82(15):5203–5207. doi: 10.1073/pnas.82.15.5203

Morphine and other opiates from beef brain and adrenal.

A Goldstein, R W Barrett, I F James, L I Lowney, C J Weitz, L L Knipmeyer, H Rapoport
PMCID: PMC390528  PMID: 3860854

Abstract

We describe nonpeptide opioids found in extracts of beef hypothalamus and adrenal, which are recognized by antisera raised against morphine. Four have been purified to homogeneity. One is morphine. The structures of the other three have not been determined yet. None of them are derived from morphine or normorphine after extraction from the tissues. It is not known whether the opiates described here are of endogenous or exogenous origin.

Full text

PDF
5204

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blume A. J., Shorr J., Finberg J. P., Spector S. Binding of the endogenous nonpeptide morphine-like compound to opiate receptors. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4927–4931. doi: 10.1073/pnas.74.11.4927. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Davis V. E., Walsh M. J. Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction. Science. 1970 Feb 13;167(3920):1005–1007. doi: 10.1126/science.167.3920.1005. [DOI] [PubMed] [Google Scholar]
  3. Gintzler A. R., Gershon M. D., Spector S. A nonpeptide morphine-like compound: immunocytochemical localization in the mouse brain. Science. 1978 Jan 27;199(4327):447–448. doi: 10.1126/science.339350. [DOI] [PubMed] [Google Scholar]
  4. Gintzler A. R., Levy A., Spector S. Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system. Proc Natl Acad Sci U S A. 1976 Jun;73(6):2132–2136. doi: 10.1073/pnas.73.6.2132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Glasel J. A., Bradbury W. M., Venn R. F. Properties of murine anti-morphine antibodies. Mol Immunol. 1983 Dec;20(12):1419–1422. doi: 10.1016/0161-5890(83)90175-x. [DOI] [PubMed] [Google Scholar]
  6. Goldstein A., James I. F. Site-directed alkylation of multiple opioid receptors. II. Pharmacological selectivity. Mol Pharmacol. 1984 May;25(3):343–348. [PubMed] [Google Scholar]
  7. Goldstein A., Schulz R. Morphine-tolerant longitudinal muscle strip from guinea-pig ileum. Br J Pharmacol. 1973 Aug;48(4):655–666. doi: 10.1111/j.1476-5381.1973.tb08254.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  9. Handa B. K., Land A. C., Lord J. A., Morgan B. A., Rance M. J., Smith C. F. Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors. Eur J Pharmacol. 1981 Apr 9;70(4):531–540. doi: 10.1016/0014-2999(81)90364-2. [DOI] [PubMed] [Google Scholar]
  10. Hazum E., Sabatka J. J., Chang K. J., Brent D. A., Findlay J. W., Cuatrecasas P. Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (mu) receptors? Science. 1981 Aug 28;213(4511):1010–1012. doi: 10.1126/science.6267691. [DOI] [PubMed] [Google Scholar]
  11. James I. F., Fischli W., Goldstein A. Opioid receptor selectivity of dynorphin gene products. J Pharmacol Exp Ther. 1984 Jan;228(1):88–93. [PubMed] [Google Scholar]
  12. Killian A. K., Schuster C. R., House J. T., Sholl S., Connors M., Wainer B. H. A non-peptide morphine-like compound from brain. Life Sci. 1981 Feb 16;28(7):811–817. doi: 10.1016/0024-3205(81)90165-x. [DOI] [PubMed] [Google Scholar]
  13. Kirby G. W. Biosynthesis of the morphine alkaloids. Science. 1967 Jan 13;155(3759):170–173. doi: 10.1126/science.155.3759.170. [DOI] [PubMed] [Google Scholar]
  14. Oka K., Kantrowitz J. D., Spector S. Isolation of morphine from toad skin. Proc Natl Acad Sci U S A. 1985 Mar;82(6):1852–1854. doi: 10.1073/pnas.82.6.1852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shorr J., Foley K., Spector S. Presence of a non-peptide morphine-like compound in human cerebrospinal fluid. Life Sci. 1978 Nov 13;23(20):2057–2062. doi: 10.1016/0024-3205(78)90239-4. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES